Evidence map›Paper›PMID 31534193›Full record

ArticleBone marrow transplantation2020

Clostridium Difficile infections in patients with AML or MDS undergoing allogeneic hematopoietic stem cell transplantation identify high risk for adverse outcome.

Simon Amberge, Michael Kramer, Percy Schröttner, Katharina Heidrich, Renate Schmelz, Jan M Middeke, Florian Gunzer, Jochen Hampe, Johannes Schetelig, Martin Bornhäuser and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Prevalence ofFrontiers in cellular and infection microbiology · 2022
    Pooled it
  3. Article
  4. Insights into PediatricBiomedicines · 2025
    Review
  5. Article
  6. Article
  7. Journal of clinical medicine · 2022
    Review
  8. Risk Factors and Outcome ofJournal of clinical medicine · 2020
    Article
  9. Pre-transplantCell transplantation
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Simon AmbergeDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany. simon.amberge@uniklinikum-dresden.de.
Michael KramerDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Percy SchröttnerInstitute of Medical Microbiology and Hygiene, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Katharina HeidrichDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Renate SchmelzDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Jan M MiddekeDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Florian GunzerInstitute of Medical Microbiology and Hygiene, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Jochen HampeDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Johannes ScheteligDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Martin BornhäuserDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
Friedrich StölzelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden University of Technology Dresden, Dresden, Germany.
University Hospital Carl Gustav Carus · DEDeutsche Knochenmarkspenderdatei · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridium difficile (CD) infection is the main cause of nosocomial enterocolitis in western countries and in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHCT). Recipients of alloHCT are at high risk for CD infection but large studies in this population are rare and conflicting results have been reported. We analyzed 727 patients with AML or MDS undergoing alloHCT in our center from 2004 to 2015. Ninety-six patients (13%) had CD infection and 103 patients (14%) were identified as asymptomatic carriers by screening at admission and once a week during aplasia. Patients with CD infection had a shorter median overall survival of 8 months (95% CI, 6-36 months) compared with 25 months (95% CI, 17-35 months) for patients without CD infection, (HR 1.4, p = 0.04). CD positive patients were less likely to develop acute graft-versus-host disease (aGvHD; HR 0.6, p = 0.004) compared with CD-negative patients, but did not show differences in gastrointestinal aGvHD (HR 0.9, p = 0.5). Symptomatic patients developed gastrointestinal aGvHD (HR 2.5, p = 0.02) more often compared with asymptomatic CD positive patients. This analysis demonstrates a high prevalence for CD infection in patients undergoing alloHCT. A significant lower overall survival for patients with CD infection could be demonstrated.

Indexed as

Clostridium InfectionsGraft vs Host DiseaseHematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteHumansRetrospective StudiesTransplantation, Homologous

Identifiers

PMID31534193
OpenAlexW2973445395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.