Evidence map›Paper›PMID 31533989›Full record

ArticleThe Journal of biological chemistry2019

Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker.

Antonina A Berkut, Anton O Chugunov, Konstantin S Mineev, Steve Peigneur, Valentin M Tabakmakher, Nikolay A Krylov, Peter B Oparin, Alyona F Lihonosova, Ekaterina V Novikova, Alexander S Arseniev and 4 more

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antonina A BerkutM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Anton O ChugunovM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia.
Konstantin S MineevM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia.
Steve PeigneurToxicology and Pharmacology, University of Leuven, 3000 Leuven, Belgium.
Valentin M TabakmakherM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; School of Biomedicine, Far Eastern Federal University, 690950 Vladivostok, Russia.
Nikolay A KrylovM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia.
Peter B OparinM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Alyona F LihonosovaNational Research University Higher School of Economics, 101000 Moscow, Russia.
Ekaterina V NovikovaM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia.
Alexander S ArsenievM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia.
Eugene V GrishinM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Jan TytgatToxicology and Pharmacology, University of Leuven, 3000 Leuven, Belgium.
Roman G EfremovM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia. Electronic address: efremov@nmr.ru.
Alexander A VassilevskiM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; Moscow Institute of Physics and Technology (State University), 141700 Dolgoprudny, Russia. Electronic address: avas@ibch.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tk-hefu is an artificial peptide designed based on the α-hairpinin scaffold, which selectively blocks voltage-gated potassium channels K

Indexed as

Amino Acid SequenceAnimalsHumansKv1.3 Potassium ChannelLigandsMagnetic Resonance SpectroscopyMass SpectrometryMolecular Dynamics SimulationMutationPeptidesPotassium Channel BlockersProtein BindingProtein ConformationProteinsSurface PropertiesKv1.3 Potassium ChannelLigandsPeptidesPotassium Channel BlockersProteinsalpha-hairpininhefutoxinion channelmolecular dynamicsneurotoxinnuclear magnetic resonance (NMR)peptidespore blockerpotassium channelprotein motifprotein structure

Identifiers

PMID31533989
PMCPMC6885618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.