Evidence map›Paper›PMID 31533968›Full record

ArticleBioscience reports2019

MicroRNA-202 inhibits cell migration and invasion through targeting FGF2 and inactivating Wnt/β-catenin signaling in endometrial carcinoma.

Ping Chen, Tianrong Xing, Qingdong Wang, Ai Liu, Haiping Liu, Yuhong Hu, Yanjia Ji, Ying Song, Dongwei Wang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor.International journal of molecular sciences · 2022
    Review
  6. MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Role of alternative splicing events in endometrial cancer prognosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  8. Review
  9. Immune-related geneTranslational cancer research · 2021
    Article
  10. Article
  11. Non-Coding RNAs as Prognostic Markers for Endometrial Cancer.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ping ChenDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Tianrong XingDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Qingdong WangDepartment of Anesthesiology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Ai LiuDepartment of Gynaecology and Obstetrics, People's Hospital of Zoucheng, Jining 273500, Shandong Province, P.R. China.
Haiping LiuDepartment of Anesthesiology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Yuhong HuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Yanjia JiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
Ying SongDepartment of Gynaecology and Obstetrics, People's Hospital of Zoucheng, Jining 273500, Shandong Province, P.R. China.
Dongwei WangDepartment of Anesthesiology, The First Affiliated Hospital of Jiamusi University, Heilongjiang Province 154002, P.R. China.
First Affiliated Hospital of Jiamusi University · CNZoucheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, many mircroRNAs (miRNAs) involved in the development and progression of cancer have been reported to regulate cell growth and metastasis, including microRNA-202 (miR-202). The purpose of the present study was to elucidate the effect of miR-202 on endometrial carcinoma (EC) cell migration and invasion. First, qRT-PCR showed that miR-202 was down-regulated in EC tissues, which was associated with poor prognosis in EC patients. Functionally, transwell assay indicated that miR-202 inhibited cell migration and invasion in EC cells. In addition, miR-202 also blocked epithelial-mesenchymal transition (EMT) through suppressing N-cadherin and Vimentin expressions and promoting E-cadherin expression. Moreover, the dual-luciferase reporter assay showed that fibroblast growth factor 2 (FGF2) is a direct target gene for miR-202 in EC cells. Furthermore, up-regulation of FGF2 attenuated the inhibitory effect of miR-202 on cell migration and invasion in EC. Besides that, miR-202 inactivated the Wnt/β-catenin signaling by suppressing β-catenin expression in EC. In conclusion, miR-202 inhibited cell migration and invasion by targeting FGF2 and inactivating the Wnt/β-catenin signaling in EC.

Indexed as

Cell MovementWnt Signaling Pathwaybeta CateninCell Line, TransformedEndometrial NeoplasmsFemaleFibroblast Growth Factor 2HumansMicroRNAsNeoplasm InvasivenessNeoplasm ProteinsRNA, Neoplasmbeta CateninCTNNB1 protein, humanFibroblast Growth Factor 2MicroRNAsMIRN202 microRNA, humanNeoplasm ProteinsRNA, Neoplasmcell invasioncell migrationendometrial carcinomaFGF2miR-202

Identifiers

PMID31533968
PMCPMC6822492
OpenAlexW2974018028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.