Evidence map›Paper›PMID 31533952›Full record

ArticleThe Journal of general physiology2019

Progressive recruitment of distal MEC-4 channels determines touch response strength in

Samata Katta, Alessandro Sanzeni, Alakananda Das, Massimo Vergassola, Miriam B Goodman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Physics of mechanotransduction by Piezo ion channels.The Journal of general physiology · 2022
    Review
  6. Article
  7. A quantal code for touch intensity inThe Journal of general physiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Samata KattaNeuroscience Program, Stanford University, Stanford, CA.ORCID 0000-0001-9748-1653
Alessandro SanzeniNational Institute of Mental Health Intramural Program, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-8758-1810
Alakananda DasDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA.
Massimo VergassolaDepartment of Physics, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-7212-8244
Miriam B GoodmanNeuroscience Program, Stanford University, Stanford, CA mbgoodman@stanford.edu.ORCID 0000-0002-5810-1272
Stanford University · USNational Institutes of Health · USUniversity of California San Diego · US

Funding

The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
Molecular Basis of Sensory Transduction in C. elegansR01NS047715 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2004 to 2017
$4.9M
Determinants of Mechanotransduction SensitivityF31NS093825 · NINDS · STANFORD UNIVERSITY · PI KATTA, SAMATA · 2015 to 2016
$69k
NINDS NIH HHS F31 NS093825NINDS NIH HHS R01 NS047715NINDS NIH HHS R35 NS105092
6 · The paper itself

Abstract

Touch deforms, or strains, the skin beyond the immediate point of contact. The spatiotemporal nature of the touch-induced strain fields depend on the mechanical properties of the skin and the tissues below. Somatosensory neurons that sense touch branch out within the skin and rely on a set of mechano-electrical transduction channels distributed within their dendrites to detect mechanical stimuli. Here, we sought to understand how tissue mechanics shape touch-induced mechanical strain across the skin over time and how individual channels located in different regions of the strain field contribute to the overall touch response. We leveraged

Indexed as

AnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsComputer SimulationGene Expression RegulationMechanotransduction, CellularMembrane ProteinsModels, BiologicalSensory Receptor CellsTouchCaenorhabditis elegans ProteinsMec-4 protein, C elegansMembrane Proteins

Identifiers

PMID31533952
PMCPMC6785734
OpenAlexW2980258748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.