Evidence map›Paper›PMID 31533857›Full record

ArticleJournal of ovarian research2019

Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer.

Wen Yu, Zhongxue Ye, Xi Fang, Xingzhi Jiang, Yafen Jiang

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In one paragraph

Article in Journal of ovarian research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen YuDepartment of Gynecology, HwaMei Hospital, University Of Chinese Academy Of Sciences, NO 41, Xibei Street, Ningbo City, 315000, Zhejiang Province, China.
Zhongxue YeDepartment of Gynecology, HwaMei Hospital, University Of Chinese Academy Of Sciences, NO 41, Xibei Street, Ningbo City, 315000, Zhejiang Province, China.
Xi FangDepartment of Gynecology, HwaMei Hospital, University Of Chinese Academy Of Sciences, NO 41, Xibei Street, Ningbo City, 315000, Zhejiang Province, China.
Xingzhi JiangDepartment of Gynecology, HwaMei Hospital, University Of Chinese Academy Of Sciences, NO 41, Xibei Street, Ningbo City, 315000, Zhejiang Province, China.
Yafen JiangDepartment of Gynecology, HwaMei Hospital, University Of Chinese Academy Of Sciences, NO 41, Xibei Street, Ningbo City, 315000, Zhejiang Province, China. jiangyafennb@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpithelial ovarian cancer (EOC) is the majority ovarian cancer (OC) type with a poor prognosis. This present study aimed to investigate potential prognostic factors including albumin-to-fibrinogen ratio (AFR) for advanced EOC patients with neoadjuvant chemotherapy (NAC) followed by debulking surgery.

methodsA total of 313 advanced EOC patients with NAC followed by debulking surgery from 2010 to 2017 were enrolled. The predictive value of AFR for the overall survival (OS) was evaluated by receiver operating characteristic (ROC) curve analysis. The univariate and multivariate Cox proportional hazards regression analyses were applied to investigate prognostic factors for advanced EOC patients. The association between preoperative AFR and progression free survival (PFS) or OS was determined via the Kaplan-Meier method using log-rank test.

resultsThe ROC curve analysis showed that the cutoff value of preoperative AFR in predicting OS was determined to be 7.78 with an area under the curve (AUC) of 0.773 (P < 0.001). Chemotherapy resistance, preoperative CA125 and AFR were independent risk factors for PFS in advanced EOC patients. Furthermore, chemotherapy resistance, residual tumor and AFR were significant risk factors for OS by multivariate Cox analysis. A low preoperative AFR (≤7.78) was significantly associated with a worse PFS and OS via the Kaplan-Meier method by log-rank test (P < 0.001).

conclusionsA low preoperative AFR was an independent risk factor for PFS and OS in advanced EOC patients with NAC followed by debulking surgery.

Indexed as

AdultAgedCA-125 AntigenCarcinoma, Ovarian EpithelialCytoreduction Surgical ProceduresDisease-Free SurvivalDrug-Related Side Effects and Adverse ReactionsDrug Resistance, NeoplasmDrug TherapyFemaleFibrinogenHumansMiddle AgedPrognosisSerum AlbuminCA-125 AntigenFibrinogenSerum AlbuminAlbumin-to-fibrinogen ratioEpithelial ovarian cancerPrognosis, chemotherapy resistance

Identifiers

PMID31533857
PMCPMC6751810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.