Evidence map›Paper›PMID 31533814›Full record

Trial reportBMC research notes2019

Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis.

Thomas B Voigt, Timothy W Tourville, Michael J Falcone, James R Slauterbeck, Bruce D Beynnon, Michael J Toth

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190046 (Muscle Disuse and Contractile Dysfunction in the Elderly), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01190046 nacompletednot on this map

Muscle Disuse and Contractile Dysfunction in the Elderly

TypeinterventionalSponsorUniversity of VermontRan2010 to 2016Enrolled35ConditionsOsteoarthritisArmsResistance exercise training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026
    Review
  3. Article
  4. The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  5. Article
  6. Effects of an exercise-based oncology rehabilitation program and age on strength and physical function in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas B VoigtDepartment of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA.
Timothy W TourvilleDepartment of Orthopedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, VT, USA.
Michael J FalconeDepartment of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA.
James R SlauterbeckDepartment of Orthopedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, VT, USA.
Bruce D BeynnonDepartment of Orthopedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, VT, USA.
Michael J TothDepartment of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA. Michael.Toth@med.uvm.edu.
University of Vermont · US

Funding

Muscle disuse and contractile dysfunction in the elderlyR01AG033547 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2010 to 2014
$1.9M
NIA NIH HHS R01 AG033547NIH HHS AG-033547
6 · The paper itself

Abstract

objectiveResistance training (RT) can improve whole muscle strength without increasing muscle fiber size or contractility. Neural adaptations, which lead to greater neural activation of muscle, may mediate some of these improvements, particularly in older adults, where motor neuron denervation is common. The purpose of this study was to explore the relationship of neural adaptations, as reflected by neural cell adhesion molecule (NCAM) expression, to improvements in (1) whole muscle strength and (2) muscle fiber size following RT in older adults with knee osteoarthritis. We performed whole muscle strength measurements and immunohistochemical analysis of fiber size, type, and NCAM expression before and after a 14-week RT program.

resultsRT increased whole-muscle strength as measured by 1-repetition maximum (1-RM) leg press (P = 0.01), leg extension (P = 0.03), and knee extensor peak torque (P = 0.050), but did not alter NCAM expression. Greater NCAM expression in myosin heavy chain (MHC) II fibers was associated with greater whole muscle strength gains (knee extensor peak torque r = 0.93; P < 0.01) and greater MHC II fiber size (r = 0.79; P < 0.01). Our results suggest that training-induced NCAM expression, and neural adaptations more generally, may be important for RT-induced morphological and functional improvements in older adults. Trial registration NCT01190046.

Indexed as

Adaptation, PhysiologicalAgedFemaleHumansKneeKnee JointMaleMiddle AgedMuscle Fibers, SkeletalMuscle, SkeletalMuscle StrengthNeural Cell Adhesion MoleculesOsteoarthritis, KneeResistance TrainingTorqueNeural Cell Adhesion MoleculesAgingDenervationExerciseHypertrophyOsteoarthritisReinnervation

Identifiers

PMID31533814
PMCPMC6751848
OpenAlexW2974640739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.