SynthesisCritical care (London, England)2019
Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials.
Synthesis in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05666908 (High-flow Nasal Oxygenation Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-flow Nasal Oxygenation Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation: a Randomized Controlled Study
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- The comparison of preoxygenation methods before endotracheal intubation: a network meta-analysis of randomized trials.Frontiers in medicine · 2024Pooled it
- Assessment of prehospital tracheal intubation technique using initial direct laryngoscopy during videolaryngoscopy: randomized controlled simulated trial.BMC emergency medicine · 2025Trial
- Bag-Mask Ventilation Versus Apneic Oxygenation During Tracheal Intubation in Critically Ill Adults: A Secondary Analysis of 2 Randomized Trials.Journal of intensive care medicine · 2022Trial
- Trial
- Ten tips for a safe approach in airway management.Journal of anesthesia, analgesia and critical care · 2026Review
- [Focus on emergency medicine 2024/2025 : Summary of selected studies in emergency medicine].Die Anaesthesiologie · 2026Article
- Emergency Department Use of Airway Adjuncts in the Setting of Endotracheal Intubation for Traumatic Injury.The Journal of emergency medicine · 2025Article
- Non-Invasive Positive Pressure Ventilation for Pre-Oxygenation of Critically Ill Patients Before Intubation.Journal of clinical medicine · 2025Review
- Non-invasive ventilation for preoxygenation during prehospital anaesthesia - a prospective observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Utilization of non-invasive ventilation before prehospital emergency anesthesia in trauma - a cohort analysis with machine learning.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Optimising oxygenation prior to and during tracheal intubation in critically ill patients.Indian journal of anaesthesia · 2024Article
- [Use of noninvasive ventilation for preoxygenation during emergency intubation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Preoxygenation and apneic oxygenation in emergency airway management.Clinical and experimental emergency medicine · 2024Article
- [Ten key messages of the S2k guideline on noninvasive mechanical ventilation in acute respiratory failure].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Review
- Approach to the Physiologically Challenging Endotracheal Intubation in the Intensive Care Unit.Respiratory care · 2023Review
- Managing the Physiologically Difficult Airway in Critically Ill Adults.Critical care (London, England) · 2023Review
- Article
- Influence of Non-invasive Ventilation in an Adult Patient With Acute Epiglottitis: A Case Report.Cureus · 2022Article
- Use of a human patient simulator for apnea studies: a preliminary in vitro trial.Korean journal of anesthesiology · 2022Article
- Tracheal Intubation in Emergency Departments in China: A National Cross-Sectional Survey.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with acute hypoxemic respiratory failure are at risk for life-threatening complications during endotracheal intubation. Preoxygenation might help reduce the risk of hypoxemia and intubation-related complications. This network meta-analysis summarizes the efficacy and safety of preoxygenation methods in adult patients with acute hypoxemic respiratory failure.
methodsWe searched PubMed, EMBASE, and the Cochrane Library Central Register of Controlled Trials through April 2019 for randomized controlled trials (RCT) that studied the use of conventional oxygen therapy (COT), high-flow nasal cannula (HFNC), noninvasive ventilation (NIV), and HFNC and NIV as preoxygenation before intubation in patients with acute hypoxemic respiratory failure. Citations' screening, study selection, data extraction, and risk of bias assessment were independently performed by two authors. The primary outcome was the lowest SpO
resultsWe included 7 RCTs (959 patients). Patients preoxygenated with NIV had significantly less desaturation than patients treated with COT (mean difference, MD 5.53, 95% CI 2.71, 8.34) and HFNC (MD 3.58, 95% CI 0.59, 6.57). Both NIV (odds ratio, OR 0.43, 95% CI 0.21, 0.87) and HFNC (OR 0.49, 95% CI 0.28, 0.88) resulted in a lower risk of intubation-related complications than COT. There were no significant mortality differences among the use of NIV, HFNC, COT, and HFNC and NIV during preoxygenation.
conclusionsIn adult patients with acute hypoxemic respiratory failure, NIV is a safe and probably the most effective preoxygenation method.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.