ArticleCritical care (London, England)2019
Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Beyond the Spontaneous Breathing Trial: Echocardiographic and Integrated Ultrasound Assessment During Weaning from Mechanical Ventilation.Diagnostics (Basel, Switzerland) · 2026Review
- Admission NT-proBNP as a Prognostic Biomarker for Ventilator Weaning Failure: Implications for Tracheostomy Timing.Biomedicines · 2026Article
- Prediction of weaning outcomes from mechanical ventilation in critically ill patients based on the combination of ultrasound parameters of the heart, lung, and diaphragm: a prospective observational cohort study.Quantitative imaging in medicine and surgery · 2025Article
- Incidence and risk factors of weaning-induced pulmonary oedema: results from a multicentre, observational study.Critical care (London, England) · 2025Observational
- Comparison of Landiolol and Esmolol on Haemodynamic Responses During Weaning of Intensive Care Unit Patients with Reduced Ejection Fraction after Vascular Surgery.Cardiac failure review · 2025Article
- Hemodynamic monitoring during weaning from mechanical ventilation in critically ill pediatric patients: a prospective observational study.BMC pediatrics · 2024Observational
- Ultrasound evaluation of cardiac and diaphragmatic function at different positions during a spontaneous breathing trial predicting extubation outcomes: a retrospective cohort study.BMC medical imaging · 2024Article
- Heart-Lungs interactions: the basics and clinical implications.Annals of intensive care · 2024Review
- The Value of Ischemic Cardiac Biomarkers to Predict Spontaneous Breathing Trial or Extubation Failure: A Systematic Review.Journal of clinical medicine · 2024Review
- Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial.Annals of intensive care · 2024Article
- Managing respiratory muscle weakness during weaning from invasive ventilation.European respiratory review : an official journal of the European Respiratory Society · 2023Article
- Highlights from the Respiratory Failure and Mechanical Ventilation 2022 Conference.ERJ open research · 2023Article
- Cardiopulmonary interactions during ventilator weaning.Frontiers in physiology · 2023Review
- Article
- Diaphragm dysfunction, lung aeration loss and weaning-induced pulmonary oedema in difficult-to-wean patients.Annals of intensive care · 2021Article
- Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation.Annals of intensive care · 2021Article
- Determination of the Utility of Parasternal Intercostal Muscle Activity in Critically Ill Patients as a Predictor of Weaning Failure and its Association with Weaning-induced Pulmonary Edema.Journal of emergencies, trauma, and shockArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWeaning-induced cardiac pulmonary edema (WiPO) is one of the main mechanisms of weaning failure during mechanical ventilation. We hypothesized that weaning-induced cardiac ischemia (WiCI) may contribute to weaning failure from cardiac origin.
methodsA prospective cohort study of patients mechanically ventilated for at least 24 h who failed a first spontaneous breathing trial (SBT) was conducted in four intensive care units. Patients were explored during a second SBT using multiple tools (echocardiography, continuous 12-lead ST monitoring, biomarkers) to scrutinize the mechanisms of weaning failure. WiPO definition was based on three criteria (echocardiographic signs of increased left atrial pressure, increase in B-type natriuretic peptides, or increase in protein concentration during SBT) according to a conservative definition (at least two criteria) and a liberal definition (at least one criterion). WiCI was diagnosed according to the third universal definition of myocardial infarction proposed by the European Society of Cardiology (ESC) and the American Heart Association (AHA) statement for exercise testing.
resultsAmong patients who failed a first SBT, WiPO occurred in 124/208 (59.6%) and 44/208 (21.2%) patients, according to the liberal and conservative definition, respectively. Among patients with ST monitoring, WiCI was diagnosed in 36/177 (20.3%) and 12/177 (6.8%) of them, according to the ESC and AHA definitions, respectively. WiCI was not associated with WiPO and was not associated with weaning outcomes. Only two patients of the cohort were treated for an acute coronary syndrome after the second SBT, and seven other patients required coronary angiography during the weaning period.
conclusionsThis observational study showed the common occurrence of pulmonary edema in mechanically ventilated patients who failed a first SBT, but the association with cardiac ischemia and weaning outcomes was weak.
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