Evidence map›Paper›PMID 31533772›Full record

ReviewCritical care (London, England)2019

Metabolic support in the critically ill: a consensus of 19.

Jan Wernerman, Kenneth B Christopher, Djillali Annane, Michael P Casaer, Craig M Coopersmith, Adam M Deane, Elisabeth De Waele, Gunnar Elke, Carole Ichai, Constantine J Karvellas and 9 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jan WernermanDepartment of Anaesthesia and Intensive Care Medicine, Karolinska Institutet, 14186, Stockholm, Sweden.
Kenneth B ChristopherDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Djillali AnnaneGeneral ICU, Hôpital Raymond Poincaré APHP, Garches, France.
Michael P CasaerClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium.
Craig M CoopersmithDepartment of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, USA.
Adam M DeaneDepartment of Medicine and Radiology, Royal Melbourne Hospital, The University of Melbourne, Melbourne Medical School, Parkville, VIC, 3050, Australia.
Elisabeth De WaeleICU Department, Nutrition Department, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
Gunnar ElkeDepartment of Anaesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany.
Carole IchaiDepartment of Anesthesiology and Intensive Care Medicine, Adult Intensive Care Unit, Université Côte d'Azur, Nice, France.
Constantine J KarvellasDivision of Gastroenterology and Department of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, AB, Canada.
Stephen A McClaveDivision of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY, USA.
Heleen M Oudemans-van StraatenDepartment of Intensive Care, Amsterdam UMC, VU University, Amsterdam, Netherlands.
Olav RooyackersAnesthesiology and Intensive Care, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, Huddinge, Sweden.
Renee D StapletonDivision of Pulmonary and Critical Care Medicine , Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Jukka TakalaDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.
Arthur R H van ZantenDepartment of Intensive Care Medicine, Gelderse Vallei Hospital, 6716 RP, Ede, Netherlands.
Paul E WischmeyerDepartment of Anesthesiology and Surgery, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Jean-Charles PreiserDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxelles, 1070, Brussels, Belgium.
Jean-Louis VincentDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxelles, 1070, Brussels, Belgium. jlvincent@intensive.org.ORCID 0000-0001-6011-6951

Funding

Pharmacokinetics and metabolomics of vitamin D supplementation in critical illnessR01GM115774 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTOPHER, KENNETH BRUCE · 2016 to 2018
$940k
NIGMS NIH HHS R01 GM115774
6 · The paper itself

Abstract

Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of illness, and the many confounding factors have hindered progress in the field. These factors may explain why management of metabolic alterations and related conditions in critically ill patients has for many years been guided by recommendations based essentially on expert opinion. Over the last decade, a number of randomized controlled trials have been conducted, providing us with important population-level evidence that refutes several longstanding paradigms. However, between-patient variation means there is still substantial uncertainty when translating population-level evidence to individuals. A cornerstone of metabolic care is nutrition, for which there is a multifold of published guidelines that agree on many issues but disagree on others. Using a series of nine questions, we provide a review of the latest data in this field and a background to promote efforts to address the need for international consistency in recommendations related to the metabolic care of the critically ill patient. Our purpose is not to replace existing guidelines, but to comment on differences and add perspective.

Indexed as

Critical IllnessGastrointestinal MicrobiomeMetabolic DiseasesConsensusEnergy IntakeHumansNutritional Physiological PhenomenaPractice Guidelines as TopicAutophagyGut dysfunctionMetabolomicsPermissive underfeedingPersonalized careProtein requirementsRelevant outcomes

Identifiers

PMID31533772
PMCPMC6751850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.