ArticleArteriosclerosis, thrombosis, and vascular biology2019
Coronary Artery Disease Risk-Associated
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Genetic associations with alcohol drinking initiation and cessation in sub-Saharan African and African ancestry populations.Research square · 2026Article
- Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Regulation for differential control.Nature chemical biology · 2026Article
- A Large-Scale Multi-omics Polygenic Risk Score Analysis Identified Candidate Biomarkers Associated with Heel Bone Mineral Density.Calcified tissue international · 2026Article
- A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions.Frontiers in cardiovascular medicine · 2026Review
- RNA Modifications in Health and Disease.MedComm · 2025Review
- Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells.Scientific reports · 2025Article
- scPanel: a tool for automatic identification of sparse gene panels for generalizable patient classification using scRNA-seq datasets.Briefings in bioinformatics · 2024Article
- From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling.Molecules (Basel, Switzerland) · 2024Review
- Glucocorticoid resistance remodels liver lipids and prompts lipogenesis, eicosanoid, and inflammatory pathways.Prostaglandins & other lipid mediators · 2024Review
- The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies.The American journal of pathology · 2024Review
- Article
- Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases.International journal of molecular sciences · 2023Review
- Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content.Metabolites · 2023Article
- Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3) Increases Cardiac Inflammation After Myocardial Infarction.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- FTO-dependent mNature communications · 2023Article
- Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease.Biomolecules · 2023Article
- Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells.Biology open · 2023Article
- Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content.Life sciences · 2022Article
- Bioactive lipids and metabolic syndrome-a symposium report.Annals of the New York Academy of Sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Paul A MuellerFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Liping YangFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Margo UbeleFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Guogen MaoFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Jason BrandonFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Julia VandraFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Timothy C NicholsDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill (T.C.N.).
Diana Escalante-AlcaldeDivisión de Neurociencias, Instituto de Fisiología, Celular Universidad Nacional Autónoma de México, Ciudad de México, CDMX (D.E.-A.).
Andrew J MorrisFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
Susan S SmythFrom the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.).
University of Kentucky · USUniversidad Nacional Autónoma de México · MXUniversity of North Carolina at Chapel Hill · US
Funding
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7MTHROMBOSPONDIN1 MEDIATES MACROPHAGE INFILTRATION INTO ADIPOSE TISSUE AND PROMOTEP20RR021954 · NCRR · UNIVERSITY OF KENTUCKY · PI ECKHARDT, ERIK · 2008 to 2011
$8.3MPilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI PEARSON, KEVIN JOSEPH · 2018 to 2022
$5.7MLipid phosphate phosphatase 3 as a novel atherosclerosis suppressorR01HL120507 · NHLBI · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J, SMYTH, SUSAN S. · 2015 to 2018
$2.1MInterdisciplinary Cardiovascular Training ProgramT32HL072743 · NHLBI · UNIVERSITY OF KENTUCKY · PI RANDALL, DAVID C · 2004 to 2013
$1.3MKentucky Center for Clinical and Translational ScienceTL1TR000115 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$518kAdipose autotaxin: a novel link between obesity and cardiovascular diseaseI01BX002769 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI SMYTH, SUSAN S. · 2015 to 2018
–Lysophosphatidic acid and cardiovascular disease riskI01CX001550 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI MORRIS, ANDREW J · 2017 to 2021
–Association of a common variant of the PPAP2B gene with cardiovascular disease.I01BX001984 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI MORRIS, ANDREW J · 2013 to 2016
–Acquisition of an HPLC Electrospray/chemical ionization triple quadrupole linear ion trap mass spectrometer system.IS1BX003153 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI MORRIS, ANDREW J · 2015 to 2015
–BLRD VA I01 BX001984BLRD VA I01 BX002769BLRD VA IS1 BX003153CSRD VA I01 CX001550NCATS NIH HHS TL1 TR000115NCATS NIH HHS UL1 TR001998NCRR NIH HHS P20 RR021954NHLBI NIH HHS R01 HL120507NHLBI NIH HHS T32 HL072743NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211
Abstract
objectiveGenome-wide association studies identified novel loci in
conclusionsOur results identify a novel lipid signaling pathway that regulates inflammation in the context of atherosclerosis and is not related to traditional risk factors. Pharmacological targeting of bioactive LPP3 substrates, including LPA, may offer an orthogonal approach to lipid-lowering drugs for mitigation of coronary artery disease risk.
Indexed as
AnimalsCells, CulturedCoronary Artery DiseaseDisease Models, AnimalFemaleHumansMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphatidate PhosphataseSignal TransductionPhosphatidate PhosphatasePLPP3 protein, humanPlpp3 protein, mouseatherosclerosiscoronary artery diseaselipid phosphate phosphataselysophosphatidic acidlysophospholipids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.