ArticleJournal of Korean Neurosurgical Society2020
The Effect of Hypnotics on Sleep Quality and Cognitive Function in Patients with Brain Tumors.
Article in Journal of Korean Neurosurgical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Prevalence, risk factors, and impacts of sleep disturbances in patients with primary brain tumors: a systematic review.Neurosurgical review · 2025Pooled it
- Proposal for Managing Cancer-Related Insomnia: A Systematic Literature Review of Associated Factors and a Narrative Review of Treatment.Cancer medicine · 2024Pooled it
- Symptom network and latent profile analysis in patients after glioma surgery: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The Effect of Preoperative Medication Intervention on Early Postoperative Cognitive Function in Elderly Patients With Poor Sleep Quality.Anesthesiology research and practice · 2026Article
- Sleep disturbances in brain tumors: a narrative review.Frontiers in oncology · 2025Review
- Palliative Care in Neuro-oncology: an Update.Current neurology and neuroscience reports · 2023Review
- Sleep disturbance in primary brain tumor: prevalence, risk factors, and patient preferences.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Association of Zolpidem With Increased Mortality in Patients With Brain Cancer: A Retrospective Cohort Study Based on the National Health Insurance Service Database.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Rehabilitation of Adult Patients with Primary Brain Tumors: A Narrative Review.Brain sciences · 2020Review
- Association Between the Use of Non-benzodiazepine Hypnotics and Cognitive Outcomes: A Systematic Review.Current sleep medicine reports · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe investigated the effect of hypnotics on sleep quality, cognitive function, and depressive mood in patients with insomnia following brain tumor resection.
methodsFrom patients who underwent brain tumor resection, we recruited 10 patients with insomnia who received hypnotics for more than 1 week during a 3-week follow-up period (insomnia group). We also recruited 12 control patients with brain tumors but without insomnia (control group). We evaluated sleep quality at baseline and 3 weeks later using the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), the Stanford Sleepiness Scale (SSS), and the Epworth Sleepiness Scale (ESS) and investigated cognitive function and depression using the Computerized Neuropsychological Test and the Beck Depression Inventory (BDI).
resultsAt baseline, SSS, ISI, PSQI, and BDI scores were significantly higher and visual continuous performance test (VCPT) and auditory continuous performance test (ACPT) scores were significantly lower in the insomnia than in the control group. Three weeks later, the patients who had received hypnotics had significantly higher ISI, PSQI, ESS, VCPT, ACPT, visual span forward and backward, and visual recognition test scores, and significantly lower BDI scores.
conclusionQuality of sleep in patients with insomnia following brain tumor resection was initially poor but improved significantly after taking hypnotic medication. Further, the hypnotic medications appeared to contribute to the amelioration of cognitive impairments and depressive moods in patients who previously underwent brain tumor resection. We thus recommend the use of hypnotics for patients with brain tumors with insomnia.
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