Evidence map›Paper›PMID 31533368›Full record

ArticleInternational journal of molecular sciences2019

Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents.

Fabienne Hilgers, Nora Lisa Bitzenhofer, Yannic Ackermann, Alina Burmeister, Alexander Grünberger, Karl-Erich Jaeger, Thomas Drepper

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Laser-Free Photosensitive Systems in Cancer Therapy: A Comprehensive Review.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Design of AsLOV2 domain as a carrier of light-induced dissociable FMN photosensitizer.Protein science : a publication of the Protein Society · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Antimicrobial Peptides Pom-1 and Pom-2 fromPathogens (Basel, Switzerland) · 2021
    Article
  11. Genetically Encoded Red Photosensitizers with Enhanced Phototoxicity.International journal of molecular sciences · 2020
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fabienne HilgersInstitute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich GmbH, D-52428 Jülich, Germany. f.hilgers@fz-juelich.de.ORCID 0000-0002-8749-284X
Nora Lisa BitzenhoferInstitute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich GmbH, D-52428 Jülich, Germany. n.bitzenhofer@fz-juelich.de.ORCID 0000-0002-2790-4929
Yannic AckermannInstitute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich GmbH, D-52428 Jülich, Germany. yannic.ackermann@uni-duesseldorf.de.
Alina BurmeisterMultiscale Bioengineering, Bielefeld University, D-33501 Bielefeld, Germany. a.burmeister@fz-juelich.de.ORCID 0000-0002-7987-1209
Alexander GrünbergerMultiscale Bioengineering, Bielefeld University, D-33501 Bielefeld, Germany. alexander.gruenberger@uni-bielefeld.de.
Karl-Erich JaegerInstitute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich GmbH, D-52428 Jülich, Germany. k.-e.jaeger@fz-juelich.de.ORCID 0000-0002-6036-0708
Thomas DrepperInstitute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich GmbH, D-52428 Jülich, Germany. t.drepper@fz-juelich.de.ORCID 0000-0002-0096-8084
Forschungszentrum Jülich · DE

Funding

Helmholtz Association PD-311Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen NRW Strategieprojekt BioSC (No. 313/323-400-00213)
6 · The paper itself

Abstract

Diseases caused by multi-drug resistant pathogens have become a global concern. Therefore, new approaches suitable for treating these bacteria are urgently needed. In this study, we analyzed genetically encoded photosensitizers (PS) related to the green fluorescent protein (GFP) or light-oxygen-voltage (LOV) photoreceptors for their exogenous applicability as light-triggered antimicrobial agents. Depending on their specific photophysical properties and photochemistry, these PSs can produce different toxic ROS (reactive oxygen species) such as O

Indexed as

LightAnti-Bacterial AgentsAnti-Infective AgentsBacteriaBiomarkersDose-Response Relationship, DrugEscherichia coliGenes, ReporterMicrofluidicsPhotosensitizing AgentsRecombinant ProteinsAnti-Bacterial AgentsAnti-Infective AgentsBiomarkersPhotosensitizing AgentsRecombinant Proteinsantibioticsantimicrobial photodynamic inactivation (aPDI)extracellular phototoxicityflavin-binding fluorescent protein (FbFP)green fluorescent protein (GFP)light-oxygen-voltage (LOV) proteinsoptogeneticsphotosensitizer (PS)

Identifiers

PMID31533368
PMCPMC6769541
OpenAlexW2973456656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.