ArticlePediatric nephrology (Berlin, Germany)1987
Congenital murine polycystic kidney disease. I. The ontogeny of tubular cyst formation.
Article in Pediatric nephrology (Berlin, Germany), 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 70 citations in OpenAlex.
- Genome-Based Advances in Modeling Renal Ciliopathies and Enhancing Patient Care.Kidney & blood pressure research · 2025Review
- Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease.Physiological reports · 2025Article
- Differential regulation of MYC expression byFrontiers in cell and developmental biology · 2023Article
- Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNAAmerican journal of physiology. Renal physiology · 2022Article
- Cystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression.Scientific reports · 2021Article
- PKD1-associated autosomal dominant polycystic kidney disease with glomerular cysts presenting with nephrotic syndrome caused by focal segmental glomerulosclerosis.BMC nephrology · 2019Article
- A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs.PloS one · 2018Article
- Evidence for a "Pathogenic Triumvirate" in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease.BioMed research international · 2016Review
- Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement.Journal of the American Society of Nephrology : JASN · 2012Article
- Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease.The American journal of pathology · 2010Article
- Three-dimensional imaging of embryonic mouse kidney by two-photon microscopy.The American journal of pathology · 2001Article
- Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice.The American journal of pathology · 1997Article
- Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 1993Article
- Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- The microanatomy of the intrahepatic bile duct in polycystic disease: comparison of the cpk mouse and human.Journal of experimental pathology (Oxford, England) · 1990Article
- Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation.Pediatric nephrology (Berlin, Germany) · 1988Article
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7 authors at 1 institution in 1 country.
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Abstract
In the current study, the ontogeny of tubular cyst formation was studied in the CPK mouse, a murine strain with autosomal recessive polycystic kidney disease. Utilizing the technique of intact nephron microdissection in addition to standard light and transmission electron microscopy, the earliest morphologic alterations in CPK kidneys were localized in fetal tissue at 17 days of gestation to the distal portion of developing proximal tubules. During disease progression, from birth to 21 days of postnatal age, there was a shift in the site of cystic nephron involvement from proximal tubule to collecting tubules without involvement of other nephron segments. Cysts were enlarged tubular segments which remained in continuity with other portions of the nephron and were not associated with abnormalities in the overall pattern of nephron growth or differentiation. Analysis suggested that alterations in transtubular transport in abnormally shortened proximal tubular segments of juxtamedullary nephrons may have pathogenic importance in the early stages of cyst formation, and that epithelial hyperplasia and cytoskeletal alterations may have a role in progressive proximal tubular cystic enlargement. Cellular hyperplasia of epithelial walls of normally formed tubules was a prominent feature of cyst formation and progressive enlargement in collecting tubules. Such data form the basis for future studies into specific pathophysiological processes which may be operative in specific nephron segments during different stages of cyst formation in the CPK mouse.
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