Evidence map›Paper›PMID 31533349›Full record

ArticleInternational journal of molecular sciences2019

Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity.

Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Violeta Jonušienė, Audronė Marozienė, Lina Misevičienė, Aliaksei V Yantsevich, Narimantas Čėnas

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Kinetic and Potentiometric Characteristics of Ferredoxin: NADPInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Redox Properties ofInternational journal of molecular sciences · 2024
    Article
  5. Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells.International journal of molecular sciences · 2023
    Article
  6. Thioredoxin Reductase-Type Ferredoxin: NADPAntioxidants (Basel, Switzerland) · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Aerobic Cytotoxicity of AromaticInternational journal of molecular sciences · 2020
    Article
  12. Reactions ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Aušra Nemeikaitė-ČėnienėState Research Institute Center for Innovative Medicine, Santariškių St. 5, LT-08406 Vilnius, Lithuania. ausra.ceniene@imcentras.lt.
Jonas ŠarlauskasDepartment of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania. jonas.sarlauskas@bchi.vu.lt.
Violeta JonušienėDepartment of Biochemistry and Molecular Biology, Institute of Biosciences of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania. violeta.jonusiene@gf.vu.lt.
Audronė MarozienėDepartment of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania. audrone.maroziene@bchi.vu.lt.
Lina MisevičienėDepartment of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania. lina.miseviciene@bchi.vu.lt.
Aliaksei V YantsevichInstitute of Bioorganic Chemistry, NAS of Belarus, Kuprevicha 5/2, BY-220072 Minsk, Belarus. al.yantsevich@gmail.com.
Narimantas ČėnasDepartment of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania. narimantas.cenas@bchi.vu.lt.
Vilnius University · LTInstitute of Bioorganic Chemistry · BYState Research Institute Centre for Innovative Medicine · LT

Funding

European Social Fund DOTSUT-34/09.3.3-LMT-K-712-01-0058/LSS-600000-58
6 · The paper itself

Abstract

Derivatives of tirapazamine and other heteroaromatic

Indexed as

Antineoplastic AgentsBiomarkersHumansMolecular StructureNADPNAD(P)H Dehydrogenase (Quinone)OxidantsOxidation-ReductionReactive Oxygen SpeciesTirapazamineAntineoplastic AgentsBiomarkersNADPNAD(P)H Dehydrogenase (Quinone)NQO1 protein, humanOxidantsReactive Oxygen SpeciesTirapazaminecytotoxicityoxidative stressreductive activationtirapazamine

Identifiers

PMID31533349
PMCPMC6769651
OpenAlexW2974592479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.