ArticleImmunity2019
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 155 papers.
0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
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Who cites it
155 citing papers in PubMed, 243 citations in OpenAlex.
- Temporal and transcriptional programming of effector memory B cells shapes vaccine platform-dependent humoral immunity.iScience · 2026Article
- BHLHE40 as a transcriptional rheostat: decoding microenvironmental signals in context-dependent tumor plasticity.Science China. Life sciences · 2026Review
- CD8MedComm · 2026Review
- BATF3 regulates differentiation of CD8Life science alliance · 2026Article
- Cross-reactive tissue-resident memory T lymphocytes-concepts, evidence, and open questions.Journal of translational medicine · 2026Review
- Article
- Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma.Clinical and translational science · 2026Article
- Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.Nature communications · 2026Article
- REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.The Journal of experimental medicine · 2026Article
- BHLHE40 Orchestrates Effector Tissue-Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Aligned cross-modal integration and regulatory heterogeneity characterization of single-cell multiomic data with deep contrastive learning.Genome medicine · 2026Article
- Fueling the sentinels: organelle remodeling and metabolic adaptation in tissue-resident memory T cell persistence.Frontiers in immunology · 2026Review
- Digoxin targets BHLHE40 to inhibit epithelial-mesenchymal transition in cervical cancer cells via downregulation of ANGPTL3.Journal of natural medicines · 2026Article
- Evolving role of CD8Frontiers in immunology · 2026Review
- Tissue-Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy.Cancer medicine · 2025Review
- Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease.The Journal of experimental medicine · 2025Article
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection.The Journal of experimental medicine · 2025Article
- A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells.Immunology and cell biology · 2025Article
- Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
21 authors at 8 institutions in 3 countries.
Chaofan LiDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Bibo ZhuDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Young Min SonDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Zheng WangDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Li JiangDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Min XiangDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Zhenqing YeDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA.
Kathryn E BeckermannDivision of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yue WuDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
James W JenkinsDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Peter J SiskaInternal Medicine III, University Hospital Regensburg, 93042 Regensburg, Germany; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Benjamin G VincentLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Y S PrakashDepartment of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.
Tobias PeikertDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Brian T EdelsonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Reshma TanejaDepartment of Physiology, National University of Singapore, Singapore 117593, Singapore.
Mark H KaplanDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jeffrey C RathmellCenter for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Haidong DongDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Taro HitosugiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Jie SunDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: sun.jie@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USVanderbilt University Medical Center · USIndiana University School of MedicineNational University of Singapore · SGUNC Lineberger Comprehensive Cancer CenterWashington University in St. Louis · USWinnMed · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MNEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5MThe role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2MExploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7MMolecular regulation of protective CD8 immunity against influenza infectionR01AI112844 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2015 to 2024
$4.5MMetabolic Barriers to T Cell Activation in Clear Cell Renal Cell CarcinomaR01CA217987 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2018 to 2026
$4.3MRegulation of Immune Responses to Mycobacterium tuberculosis InfectionR01AI132653 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD, STALLINGS, CHRISTINA LEIGH · 2018 to 2022
$3.0MRegulation of pulmonary anti-viral immunity in normal and obese hostsR01HL126647 · NHLBI · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.9MRole of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9MUNDERSTANDING AUTOREACTIVE T CELL PATHOGENICITYR01AI113118 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD · 2015 to 2019
$1.9MSimultaneously boosting both humoral and cellular immunity following vaccinationR01AG047156 · NIA · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.6MNCI NIH HHS K12 CA090625NCI NIH HHS R01 CA217987NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL126451NHLBI NIH HHS R01 HL126647NIAID NIH HHS R01 AI057459NIAID NIH HHS R01 AI112844NIAID NIH HHS R01 AI113118NIAID NIH HHS R01 AI132653NIA NIH HHS R01 AG047156NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK105550
Abstract
Tissue-resident memory CD8
Indexed as
AnimalsBasic Helix-Loop-Helix ProteinsCD8-Positive T-LymphocytesEpigenesis, GeneticGene Expression RegulationHomeodomain ProteinsLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLMitochondriaProgrammed Cell Death 1 ReceptorBasic Helix-Loop-Helix ProteinsBhlhe40 protein, mouseHomeodomain ProteinsProgrammed Cell Death 1 ReceptoracetateBhlhe40epigeneticmetabolismmitochondriaPD-L1tissue resident memory T cellTubastatin Atumor-infiltrating lymphocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.