ArticleCell reports2019
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.
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Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 2 of them syntheses that pooled it.
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167citing papers in PubMed, 2 pooled it
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
167 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Immune checkpoint expression in mucosal-associated invariant T cells is stimulus-dependent.Journal of leukocyte biology · 2025Pooled it
- Mining the multifunction of mucosal-associated invariant T cells in hematological malignancies and transplantation immunity: A promising hexagon soldier in immunomodulatory.Frontiers in immunology · 2022Pooled it
- Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.Clinical and experimental immunology · 2020Trial
- Gut archaea drive human MAIT cell responses.bioRxiv : the preprint server for biology · 2026Article
- Article
- 4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.Immunology and cell biology · 2026Article
- Mucosal-associated invariant T cells support IL-15-dependent Treg response in skin injury and promote resolution of skin inflammation.bioRxiv : the preprint server for biology · 2026Article
- Allelic variation alters expression and antigen presentation of MR1 allomorphs.The Journal of biological chemistry · 2026Article
- Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo.The Journal of infectious diseases · 2026Article
- Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function.Immunology · 2026Article
- The Pathophysiological Significance of Dual Inhibition of IL-17A and IL-17F in Psoriatic Arthritis and Axial Spondyloarthritis.Mediterranean journal of rheumatology · 2026Review
- Tumor-Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation.MedComm · 2026Review
- MAIT Cells Maintain Intestinal Homeostasis Through IL-22 in an Experimental Colitis.Journal of inflammation research · 2026Article
- Protective role of mucosa-associated invariant T cells in sepsis-related liver injury.Frontiers in immunology · 2026Article
- "From inflammation to fibrosis: a proposed role of mucosal-associated invariant T cells in lichen sclerosus - a conceptual framework".Frontiers in immunology · 2026Review
- Mucosal-Associated Invariant T (MAIT) Cells in Skin Immunity: Metabolic Regulation, Tissue Adaptation, and Roles in Skin Inflammation and Disease.JID innovations : skin science from molecules to population health · 2026Review
- Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026Review
- Single-cell RNA sequencing reveals heterogeneity of mucosaassociated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-Haematologica · 2026Article
- Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity.Frontiers in immunology · 2026Review
- Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
107 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors.
Tianqi LengPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.
Hossain Delowar AktherPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Carl-Philipp HacksteinPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Kate PowellPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Department of Microbiology and Immunology, University of Otago, Otago, New Zealand.
Thomas KingPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.
Matthias FriedrichThe Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Zoe ChristoforidouTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Sarah McCuaigThe Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Mastura NeyaziThe Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Carolina V Arancibia-CárcamoTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Joachim HagelPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.
Fiona PowrieThe Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Oxford IBD InvestigatorsTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Raphael Sanches PeresThe Kennedy Institute of Rheumatology, Roosevelt Dr., Oxford OX3 7FY, UK.
Val MillarTarget Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK.
Daniel EbnerTarget Discovery Institute, Roosevelt Dr., Oxford OX3 7FZ, UK.
Rajesh LamichhaneDepartment of Microbiology and Immunology, University of Otago, Otago, New Zealand.
James UssherDepartment of Microbiology and Immunology, University of Otago, Otago, New Zealand.
Timothy S C HinksNIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK; Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.
Emanuele MarchiPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.
Chris WillbergPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.
Paul KlenermanPeter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address: paul.klenerman@medawar.ox.ac.uk.
Funding
Wellcome Trust 109965/Z/15/ZWellcome Trust 211050/Z/18/Z
Abstract
MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8
Indexed as
Lymphocyte ActivationAgedAged, 80 and overCaco-2 CellsCD8-Positive T-LymphocytesCytokinesFemaleHumansInflammationMaleMiddle AgedMucosal-Associated Invariant T CellsReceptors, Antigen, T-CellSignal TransductionTHP-1 CellsCytokinesReceptors, Antigen, T-Cellcytokineseffector functionsMAIT cellsTCR signalingtissue repair
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.