Evidence map›Paper›PMID 31532870›Full record

ArticleOral diseases2020

Oral adverse effects of drugs: Taste disorders.

Willem Maria Hubertus Rademacher, Yalda Aziz, Atty Hielema, Ka-Chun Cheung, Jan de Lange, Arjan Vissink, Frederik Reinder Rozema

Open access · hybridAbstract read
In one paragraph

Article in Oral diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023
    Review
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Article
  20. Why Taste Is Pharmacology.Handbook of experimental pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Willem Maria Hubertus RademacherDepartment of Oral Medicine, Academic Center of Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.ORCID 0000-0001-6487-1356
Yalda AzizDepartment of Oral Medicine, Academic Center of Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Atty HielemaDepartment Medicine Information Centre, Royal Dutch Pharmacists Association (KNMP), Den Haag, The Netherlands.
Ka-Chun CheungDepartment Medicine Information Centre, Royal Dutch Pharmacists Association (KNMP), Den Haag, The Netherlands.
Jan de LangeDepartment of Oral and Maxillofacial Surgery, Academic UMC, University of Amsterdam, Amsterdam, The Netherlands.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-2581-4361
Frederik Reinder RozemaDepartment of Oral Medicine, Academic Center of Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Academic Center for Dentistry Amsterdam · NLRoyal Dutch Pharmacists Association · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision making whether a taste disorder can be due to use of drugs by providing a comprehensive overview of drugs with taste disorders as an adverse effect. MATERIALS AND

methodsThe national drug information database for Dutch pharmacists, based on scientific drug information, guidelines, and summaries of product characteristics, was analyzed for drug-induced taste disorders. "MedDRA classification" and "Anatomic Therapeutical Chemical codes" were used to categorize the results.

resultsOf the 1,645 drugs registered in the database, 282 (17%) were documented with "dysgeusia" and 61 (3.7%) with "hypogeusia." Drug-induced taste disorders are reported in all drug categories, but predominantly in "antineoplastic and immunomodulating agents," "antiinfectives for systemic use," and "nervous system." In ~45%, "dry mouth" coincided as adverse effect with taste disorders.

conclusionHealthcare professionals are frequently confronted with drugs reported to cause taste disorders. This article provides an overview of these drugs to support clinicians in their awareness, diagnosis, and treatment of drug-induced taste disorders.

Indexed as

Drug-Related Side Effects and Adverse ReactionsDatabases, PharmaceuticalDysgeusiaHumansPharmaceutical PreparationsTaste DisordersXerostomiaPharmaceutical Preparationsdrug-induced taste disordersdrugs adverse effectsdysgeusiahypogeusiaoral adverse effects

Identifiers

PMID31532870
PMCPMC6988472
OpenAlexW2974057769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.