Evidence map›Paper›PMID 31532715›Full record

ArticleAmerican journal of physiology. Cell physiology2019

A myosin-based mechanism for stretch activation and its possible role revealed by varying phosphate concentration in fast and slow mouse skeletal muscle fibers.

Chad R Straight, Kaylyn M Bell, Jared N Slosberg, Mark S Miller, Douglas M Swank

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Molecular regulation of stretch activation.American journal of physiology. Cell physiology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chad R StraightDepartment of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.
Kaylyn M BellDepartment of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York.
Jared N SlosbergDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York.
Mark S MillerDepartment of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.
Douglas M SwankDepartment of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York.ORCID 0000-0002-2552-4455
Rensselaer Polytechnic Institute · USUniversity of Massachusetts Amherst · US

Funding

Modulating stretch activation to restore muscle and heart functionR01AR064274 · NIAMS · RENSSELAER POLYTECHNIC INSTITUTE · PI SWANK, DOUGLAS M · 2014 to 2018
$1.2M
NIAMS NIH HHS R01 AR064274
6 · The paper itself

Abstract

Stretch activation (SA) is a delayed increase in force following a rapid muscle length increase. SA is best known for its role in asynchronous insect flight muscle, where it has replaced calcium's typical role of modulating muscle force levels during a contraction cycle. SA also occurs in mammalian skeletal muscle but has previously been thought to be too low in magnitude, relative to calcium-activated (CA) force, to be a significant contributor to force generation during locomotion. To test this supposition, we compared SA and CA force at different P

Indexed as

ActinsAdenosine TriphosphateAnimalsBiomechanical PhenomenaCalciumDrosophila melanogasterFemaleGene ExpressionIsometric ContractionMechanotransduction, CellularMiceMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchMyosinsPhosphatesTissue Culture TechniquesActinsAdenosine TriphosphateCalciumMyosinsPhosphatesforcelocomotionmousemyosinphosphateskeletal musclestretch activation

Identifiers

PMID31532715
PMCPMC6957385
OpenAlexW2974511118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.