ArticleMicrobiologyOpen2019
Effects of exogenous glucose on Pseudomonas aeruginosa biofilm formation and antibiotic resistance.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026Article
- Transcriptome-Integrated Metabolic Modeling Identifies Candidate Metabolic Adjuvants in Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Insulin Affects Biological Behaviours ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.FEMS microbiology reviews · 2026Review
- Article
- Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production.Microbial biotechnology · 2025Review
- Virulence Plasmid Modulates Glucose-Mediated Biofilm Regulation inLife (Basel, Switzerland) · 2025Article
- UropathogenicMicroorganisms · 2025Article
- Lavandula dentata leaves as potential natural antibiofilm agents against Pseudomonas aeruginosa.Scientific reports · 2025Article
- Exploring interspecies differences inJournal of medical microbiology · 2024Article
- Triple threat: how diabetes results in worsened bacterial infections.Infection and immunity · 2024Review
- Malonate is relevant to the lung environment and induces genome-wide stress responses in Pseudomonas aeruginosa.Research square · 2024Article
- Metabolomic Approaches to Study the Potential Inhibitory Effects of Plantaricin Q7 againstFoods (Basel, Switzerland) · 2024Article
- Carbon Source and Substrate Surface Affect Biofilm Formation by the Plant-Associated BacteriumInternational journal of molecular sciences · 2024Article
- Carbon source competition within the wound microenvironment can significantly influence infection progression.NPJ biofilms and microbiomes · 2024Article
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- TbsP and TrmB jointly regulate gapII to influence cell development phenotypes in the archaeon Haloferax volcanii.Molecular microbiology · 2024Article
- Prodigiosin as an Antibiofilm Agent against the Bacterial Biofilm-Associated Infection ofPathogens (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is commonly found in nosocomial and life-threatening infections in patients. Biofilms formed by P. aeruginosa exhibit much greater resistance to antibiotics than the planktonic form of the bacteria. Few groups have studied the effects of glucose, a major carbon source, and metabolite, on P. aeruginosa biofilm formation and on its metabolic pathways. In this study, we investigated the effect of glucose on the biofilm formation ability of P. aeruginosa and carried out a metabolomic analysis to identify whether glucose alters the metabolic activity of P. aeruginosa in biofilms. We found that glucose efficiently promoted P. aeruginosa biofilm formation by upregulating the expression of the extracellular polysaccharide-related gene pslA. Treatment with glucose caused an increase in 7 metabolites (including 3-hydroxypropionic acid, glucose-6-phosphate, and 2,3-dimethylsuccinic acid) and a decrease in 18 metabolites (including myo-inositol, glutamine, and methoxamedrine) in the biofilm. In addition, there was a synergistic effect between glucose and horse serum on biofilm formation when the two were added in combination, which also increased the resistance of biofilm to levofloxacin therapy. Thus, our work sheds light on the underlying mechanisms by which glucose may enhance biofilm formation and identifies novel targets for developing strategies to counteract biofilm formation.
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Registered trials
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