SynthesisNutrition reviews2019
Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies.
Synthesis in Nutrition reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06555315 (Pilot Non-inferiority Study Investigating Daily Versus Every Other Day Dosing of Oral Iron in Premature Infants.), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Non-inferiority Study Investigating Daily Versus Every Other Day Dosing of Oral Iron in Premature Infants.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Meta-analysis and Mendelian randomization study on the association between exposure to chlorinated disinfection byproducts and preterm birth risk.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- [Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Guideline
- Guideline
- Prevalence of anemia and its associated factors among children aged 6-23 months, in Ethiopia: a systematic review and meta analysis.BMC public health · 2023Pooled it
- Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life-A Secondary Outcome Analysis of a Randomized Controlled Trial.Nutrients · 2022Trial
- Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial.European journal of pediatrics · 2022Trial
- Identification and Assessment of Systematic Reviews for Evidence-Based Guideline Recommendations on Follow-Up of Preterm Born Children: A Mapping Review.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pediatric Oral Iron Therapy: Choosing the Right Product for Your Patient.Hematology reports · 2026Review
- Impact of Comprehensive Breastfeeding Support Strategies on Exclusive Breastfeeding Rates at Discharge in a Neonatal Unit.Nutrients · 2026Observational
- Ferroptosis in necrotizing enterocolitis: iron overload-driven intestinal injury and mechanistic insights.Frontiers in pediatrics · 2026Review
- Red Blood Cell Transfusion and Risk of Iron Overload in Preterm Infants: A Prospective Study on Serum Ferritin and Hepcidin.Neonatology · 2026Article
- Neurological Outcomes in Late Preterm Infants: An Updated Review of Recent Research and Clinical Insights.Diagnostics (Basel, Switzerland) · 2025Review
- The effect of iron supplementation in preterm infants at different gestational ages.BMC pediatrics · 2024Article
- The Effects of Iron Administration on Anemia Development during the 7th and 21st Day of Life in Premature Newborns: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2024Article
- Article
- Comment on: "Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial".European journal of pediatrics · 2023Article
- Prevalence and Implications of Low Reticulocyte-Hemoglobin Levels among Extreme Preterm Neonates: A Single-Center Retrospective Study.Nutrients · 2022Article
- Development of a nutritional risk screening tool for preterm children in outpatient settings during a complementary feeding period: a pilot study.BMC pediatrics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextEnteral iron supplementation in preterm infants is recommended to supply sufficient iron for growth and development without increasing the risk of iron overload. However, the current recommendations date from 2010 and are based on limited evidence.
objectiveThis systematic review aimed to investigate the effects of enteral iron supplementation on iron status, growth, neurological development, and adverse clinical outcomes in preterm (<37 weeks' gestation) and low-birth-weight (LBW, <2500 g) infants. DATA SOURCES: The PubMed/Medline and Cochrane Library databases were searched to 31 October 2018. DATA EXTRACTION: Of the 684 records identified, 27 articles, describing 18 randomized controlled trials (RCTs) plus 4 nonrandomized interventions, were included. Using the Cochrane Collaboration's criteria, study quality was found to be poor to fair overall.
resultsMost articles (23/27) reported iron status indices; supplementation for ≥8 weeks resulted in increased hemoglobin and ferritin concentrations and a reduction in iron deficiency and anemia. No article reported on iron overload. Growth-related parameters reported in 12 articles were not affected by supplementation. Among the 7 articles on neurological development, a positive effect on behavior at 3.5 and 7 years was observed in one Swedish RCT. No association was found between supplementation and adverse clinical outcomes in the 9 articles reporting on studies in which such data was collected.
conclusionsLong-term iron supplementation appears to result in improved iron status and a reduction in iron deficiency and anemia in preterm and LBW infants. However, high-quality evidence regarding the long-term effects of supplementation on functional health outcomes is lacking. Iron overload has largely been ignored. Well-designed, long-term, dose-response RCTs are required to ascertain the optimal dose and delivery method for the provision of dietary iron in preterm infants, with consideration of short- and long-term health effects. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42018085214.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.