Evidence map›Paper›PMID 31532389›Full record

ArticleeLife2019

NHR-14 loss of function couples intestinal iron uptake with innate immunity in

Malini Rajan, Cole P Anderson, Paul M Rindler, Steven Joshua Romney, Maria C Ferreira Dos Santos, Jason Gertz, Elizabeth A Leibold

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  8. Modeling Host-Pathogen Interactions inInternational journal of molecular sciences · 2024
    Review
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  14. Review
  15. Frontiers in immunology · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Malini Rajan *Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-7653-4223
Cole P Anderson *Molecular Medicine Program, University of Utah, Salt Lake City, United States.
Paul M Rindler *Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, United States.
Steven Joshua Romney *Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, United States.
Maria C Ferreira Dos SantosDepartment of Medicine, Division of Hematology, University of Utah, Salt Lake City, United States.
Jason GertzDepartment of Oncological Sciences, University of Utah, Salt Lake City, United States.
Elizabeth A LeiboldDepartment of Medicine, Division of Hematology, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0003-1000-9503
University of Utah · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
RESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4M
Genetic Analysis of Iron Homeostasis in C.ElegansR01DK068602 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN · 2006 to 2010
$1.2M
The South African Infectious Disease Clinical Research Training ProgramD43TW007115 · FIC · UNIVERSITY OF CAPE TOWN · PI HUSSEY, GREGORY D · 2004 to 2011
$888k
Impact of enhancer sequence and interacting factors on estrogen receptor-mediatedR00HG006922 · NHGRI · UNIVERSITY OF UTAH · PI GERTZ, JASON · 2014 to 2016
$811k
NCI NIH HHS P30 CA042014NHGRI NIH HHS R00 HG006922NIDDK NIH HHS R01 DK068602NIDDK NIH HHS T32 DK007115NIDDK NIH HHS U54 DK110858
6 · The paper itself

Abstract

Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In

Indexed as

Immunity, InnateSignal TransductionAnimalsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease ResistanceDNA-Binding ProteinsIronPseudomonas aeruginosaPseudomonas InfectionsReceptors, Cytoplasmic and NuclearTrace ElementsTrans-ActivatorsTranscription FactorsCaenorhabditis elegans ProteinsDNA-Binding ProteinsIronnhr-14 protein, C elegansPQM-1 protein, C elegansReceptors, Cytoplasmic and NuclearTrace ElementsTrans-ActivatorsTranscription FactorsC. eleganscell biologygeneticsgenomicsinnate immunityiron uptakeNHR-14pathogenPQM-1SMF-3

Identifiers

PMID31532389
PMCPMC6777940
OpenAlexW2974572702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.