Evidence map›Paper›PMID 31532357›Full record

ArticleMicrobial genomics2021

Molecular characterization of respiratory syncytial viruses circulating in a paediatric cohort in Amman, Jordan.

Nídia S Trovão, Najwa Khuri-Bulos, Yi Tan, Vinita Puri, Meghan H Shilts, Rebecca A Halpin, Nadia B Fedorova, Martha I Nelson, Natasha Halasa, Suman R Das

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nídia S TrovãoDivision of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Najwa Khuri-BulosDivision of Infectious Diseases, Department of Pediatrics, University of Jordan, Amman, Jordan.
Yi TanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vinita PuriInfectious Disease Group, J. Craig Venter Institute, Rockville, MD, USA.
Meghan H ShiltsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Rebecca A HalpinInfectious Disease Group, J. Craig Venter Institute, Rockville, MD, USA.
Nadia B FedorovaInfectious Disease Group, J. Craig Venter Institute, Rockville, MD, USA.
Martha I NelsonDivision of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Natasha HalasaDepartments of Pediatrics, Vanderbilt University, Nashville, TN, USA.
Suman R DasDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
J. Craig Venter Institute · USNational Institutes of Health · USUniversity of Jordan · JOVanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI NELSON, KAREN E., NIERMAN, WILLIAM CHARLES · 2014 to 2018
$29.7M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2015 to 2026
$27.5M
NCATS NIH HHS UL1 TR000445NIAID NIH HHS HHSN272201400008CNIAID NIH HHS P30 AI110527NIAID NIH HHS U19 AI110819
6 · The paper itself

Abstract

Respiratory syncytial viruses (RSVs) are an important cause of mortality worldwide and a major cause of respiratory tract infections in children, driving development of vaccine candidates. However, there are large gaps in our knowledge of the local evolutionary and transmission dynamics of RSVs, particularly in understudied regions such as the Middle East. To address this gap, we sequenced the complete genomes of 58 RSVA and 27 RSVB samples collected in a paediatric cohort in Amman, Jordan, between 2010 and 2013. RSVA and RSVB co-circulated during each winter epidemic of RSV in Amman, and each epidemic comprised multiple independent viral introductions of RSVA and RSVB. However, RSVA and RSVB alternated in dominance across years, potential evidence of immunological interactions. Children infected with RSVA tended to be older than RSVB-infected children [30 months versus 22.4 months, respectively (

Indexed as

Base SequenceChild, PreschoolCohort StudiesEvolution, MolecularGenome, ViralGenotypeHigh-Throughput Nucleotide SequencingHumansInfantJordanMiddle EastPhylogenyRespiratory Syncytial VirusesRespiratory Tract InfectionsRNA, ViralSeasonsRNA, ViralBayesian analysisevolutionnext-generation sequencingpaediatric cohortphylogenetic analysisrespiratory syncytial virus

Identifiers

PMID31532357
PMCPMC8627666
OpenAlexW2973887840

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.