Evidence map›Paper›PMID 31532068›Full record

ArticleJournal of applied clinical medical physics2019

Radiosurgery for mesial temporal lobe epilepsy following ROSE trial guidelines - A planning comparison between Gamma Knife, Eclipse, and Brainlab.

Ganesh Narayanasamy, Steven Morrill, David Cousins, Joshua Liu, Garron Deshazer, Wesley Garner, Edvaldo Galhardo, Demitre Serletis, Jose Penagaricano

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ganesh NarayanasamyDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Steven MorrillDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
David CousinsCollege Of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Joshua LiuCollege Of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Garron DeshazerDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Wesley GarnerCollege Of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Edvaldo GalhardoDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Demitre SerletisSection of Neurosurgery, Children's Hospital & Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Jose PenagaricanoDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to compare stereotactic radiosurgery (SRS) planning of epilepsy that complies with Radiosurgery or Open Surgery for Epilepsy (ROSE) guidelines in GammaKnife, non-coplanar conformal (NCC) plan in Eclipse, dynamic conformal arc (DCA) plan in Brainlab, and a volumetric modulated arc therapy (VMAT) plan in Eclipse.

methodsTwenty plans targeting Mesial temporal lobe epilepsy (MTLE) was generated using GammaKnife, Eclipse with 20 NCC beams, Brainlab with 5 DCA, and Eclipse VMAT with 4 arcs observing ROSE trial guidelines. Multivariate analysis of variance and Wilcoxon signed-rank test were used to compare dosimetric data of the plans and perform pairwise comparison, respectively.

resultsThe plans obeyed the recommended prescription isodose volume (PIV) within 5.5-7.5 cc and maximum doses to brainstem, optic apparatus (OA) of 10 and 8 Gy, respectively, for a prescription dose of 24 Gy. The volumes of the target were in the range 4.0-7.4 cc. Mean PIV, maximum dose to brainstem, OA were 6.5 cc, 10 Gy, 7.9 Gy in GammaKnife; 7.2 cc, 6.1 Gy, 4.5 Gy in Eclipse NCC; 7.2 cc, 6.4 Gy, 5.7 Gy in Brainlab DCA; and 5.2 cc, 8.4 Gy, 6.1 Gy in Eclipse VMAT plans, respectively. Multivariate analysis of variance showed significant differences among the 4 SRS planning techniques (P-values < 0.01).

conclusionsAmong the 4 SRS planning methods, VMAT with least PIV and acceptable maximum doses to brainstem and OA showed highest compliance with ROSE trial. Having the most conformal dose distribution and least dose inhomogeneity, VMAT scored higher than GK, Eclipse NCC, and Brainlab DCA plans.

Indexed as

Epilepsy, Temporal LobeHumansOrgans at RiskPractice Guidelines as TopicQuality Assurance, Health CareRadiosurgeryRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-Assistedepilepsyepilepsy Gamma Knifeepilepsy SRSROSE trialtemporal lobectomy

Identifiers

PMID31532068
PMCPMC6806476
OpenAlexW2973309921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.