Evidence map›Paper›PMID 31532058›Full record

ArticleJournal of cellular and molecular medicine2019

A gain of function paradox: Targeted therapy for glioblastoma associated with abnormal NHE9 expression.

Ashley E Pall, Lena Juratli, Dhyana Guntur, Krisanu Bandyopadhyay, Kalyan C Kondapalli

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. IDH1Scientific reports · 2023
    Article
  5. Review
  6. Review
  7. Emerging links between endosomal pH and cancer.Cancer metastasis reviews · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ashley E PallDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.
Lena JuratliDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.
Dhyana GunturDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.
Krisanu BandyopadhyayDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.
Kalyan C KondapalliDepartment of Natural Sciences, University of Michigan-Dearborn, Dearborn, MI, USA.ORCID 0000-0003-1242-9990
University of Michigan–Dearborn · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most frequent and inevitably lethal primary brain cancer in adults. It is recognized that the overexpression of the endosomal Na

Indexed as

Molecular Targeted TherapyAnimalsApoptosisBlood-Brain BarrierBrain NeoplasmsCell Line, TumorClathrinEndocytosisEndosomesErbB ReceptorsGain of Function MutationGlioblastomaGoldHumansHydrogen-Ion ConcentrationHyperthermia, InducedClathrinErbB ReceptorsGoldSLC9A9 protein, humanSodium-Hydrogen Exchangersblood-brain barrierendosomeglioblastomagold nanoparticlesneurological diseaseNHE9pHphotothermal therapySLC9A9sodium-proton exchanger

Identifiers

PMID31532058
PMCPMC6815843
OpenAlexW2973583071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.