Evidence map›Paper›PMID 31532032›Full record

ArticleMagnetic resonance in medicine2020

Inversion recovery UTE based volumetric myelin imaging in human brain using interleaved hybrid encoding.

Hyungseok Jang, Yajun Ma, Adam C Searleman, Michael Carl, Jody Corey-Bloom, Eric Y Chang, Jiang Du

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  4. Brain short TNeuroImage · 2025
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  6. Quantification of the in vivo brain ultrashort-TMagnetic resonance in medicine · 2024
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  11. Brain ultrashort TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyungseok JangDepartment of Radiology, University of California San Diego, San Diego, California.ORCID 0000-0002-3597-9525
Yajun MaDepartment of Radiology, University of California San Diego, San Diego, California.ORCID 0000-0003-0830-9232
Adam C SearlemanDepartment of Radiology, University of California San Diego, San Diego, California.
Michael CarlGE Healthcare, San Diego, California.
Jody Corey-BloomDepartment of Neurosciences, University of California, San Diego, California.
Eric Y ChangDepartment of Radiology, University of California San Diego, San Diego, California.
Jiang DuDepartment of Radiology, University of California San Diego, San Diego, California.

Funding

Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
UTE Magnetic Resonance Imaging: New Biomarkers for Multiple SclerosisR01NS092650 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2019
$1.9M
Quantitative Magnetic Resonance Imaging of Human Rotator Cuff TendonI01CX001388 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, ERIC Y · 2016 to 2024
–
Quantitative Measurement of Joint pH with Magnetic Resonance ImagingI01RX002604 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, ERIC Y · 2018 to 2022
–
CSRD VA I01 CX001388NIBIB NIH HHS T32 EB005970NINDS NIH HHS R01 NS092650RRD VA I01 RX002604
6 · The paper itself

Abstract

purposeDirect myelin imaging can improve the characterization of myelin-related diseases such as multiple sclerosis. In this study, we explore a novel method to directly image myelin using inversion recovery-prepared hybrid encoding (IR-HE) UTE MRI.

methodsThe IR-HE sequence uses an adiabatic inversion pulse to suppress the long T

resultsThe computer simulation showed that IR-interleaved HE allows for improved contrast of myelin signal with reduced imaging artifacts. The myelin phantom experiment showed IR-interleaved HE allows direct imaging of myelin lipid with excellent suppression of water signal. In the ex vivo and in vivo experiments, the proposed method demonstrated highly specific imaging of myelin in white matter of the brain.

conclusionIR-interleaved HE allows for time-efficient, high-contrast direct myelin imaging and can detect demyelinated lesions in multiple sclerosis patients.

Indexed as

Magnetic Resonance ImagingAdultAgedAlgorithmsBrainCadaverComputer SimulationFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedImaging, Three-DimensionalLipidsMaleMiddle AgedLipidshybrid encodinginversion recoverymultiple sclerosismyelinUTE

Identifiers

PMID31532032
PMCPMC6879796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.