Evidence map›Paper›PMID 31531934›Full record

ArticlePediatric transplantation2019

Pediatric intestinal transplantation: Analysis of the intestinal transplant registry.

Vikram K Raghu, Jennifer L Beaumont, Matthew J Everly, Robert S Venick, Florence Lacaille, George V Mazariegos

Open access · greenAbstract read
In one paragraph

Article in Pediatric transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
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  8. Review
  9. The Development of the International Intestinal Failure Registry and an Overview of its Results.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Organ allocation in pediatric abdominal transplant.Seminars in pediatric surgery · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Vikram K RaghuDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-6555-9732
Jennifer L BeaumontTerasaki Research Institute, Los Angeles, California.
Matthew J EverlyTerasaki Research Institute, Los Angeles, California.
Robert S VenickDivision of Pediatric Gastroenterology, Hepatology and Nutrition, David Geffen School of Medicine, UCLA, Los Angeles, California.
Florence LacailleDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Hôpital Necker Enfants Malades, Paris, France.
George V MazariegosDepartment of Surgery, Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-2624-8632
Children's Hospital of Pittsburgh · USTerasaki Foundation · USHôpital Necker-Enfants Malades · FRUniversity of California, Los Angeles · US

Funding

Digestive Diseases Training ProgramT32DK063922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARTEEL, GAVIN E, YADAV, DHIRAJ · 2003 to 2022
$5.2M
NIDDK NIH HHS 5T32DK063922-17NIDDK NIH HHS T32 DK063922
6 · The paper itself

Abstract

The ITR serves as an international database for centers around the world to contribute to current knowledge about intestinal transplant outcomes. Led by the IRTA and managed by the Terasaki Research Institute, the ITR collects data annually and uses these data to generate reports that guide management strategies and policy statements. The aim of this manuscript was to analyze outcomes specific to pediatric intestinal transplantation. Outcome data for children transplanted from 1985 to 2017 were analyzed and predictive factors assessed. A total of 2010 children received 2080 intestine containing allografts during this period. Overall, 1-year and 5-year patient and graft survival were 72.7%/66.1% and 57.2/48.8%, respectively. One-year conditional survival was most strongly associated with being a first-time transplant recipient and liver-inclusive grafts. Patient survival was most strongly associated with elective status of transplantation as compared with hospitalized status. Enteral autonomy following transplantation has continued to improve by era with colonic inclusion demonstrating additional incremental improvement in enteral autonomy and freedom from intravenous fluid. While PTLD and technical complications contribute less to graft loss than in earlier eras, rejection remains the largest contributor to long-term graft loss. Re-transplantation is linked with significantly worse conditional graft survival, and sepsis remains the largest contributor to patient death. Newer data elements are focusing on impact of donor variables, donor and recipient tissue typing, and impact of the development of de novo antibodies.

Indexed as

RegistriesChild, PreschoolDatabases, FactualFemaleGraft SurvivalHumansInfantIntestinesMaleRetrospective StudiesTreatment Outcomegraft rejectionintestinal transplantationpediatricspediatric transplantationregistriesshort bowel syndrome

Identifiers

PMID31531934
PMCPMC6879795
OpenAlexW2974086585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.