SynthesisJournal of diabetes research2019
Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis.
Synthesis in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.Annals of medicine · 2026Article
- Some Levels of Plasma Free Fatty Acids and Amino Acids in the Second Trimester Are Linked to Gestational Diabetes and Are Predictive of Persisting Impaired Glucose Tolerance After Delivery.Journal of clinical medicine · 2025Article
- Longitudinal Trajectory of Free Fatty Acids in Pregnancy According to First-Trimester Maternal Metabolic Status and the Presence of Gestational Diabetes.Metabolites · 2025Article
- Association of free fatty acid in first trimester with the risk of gestational diabetes mellitus: a nested case-control study.BMC endocrine disorders · 2024Article
- Changes in Lipid Profiles with the Progression of Pregnancy in Black Women.Journal of clinical medicine · 2024Article
- Advances in free fatty acid profiles in gestational diabetes mellitus.Journal of translational medicine · 2024Review
- Association between serum free fatty acids and gestational diabetes mellitus.Frontiers in endocrinology · 2024Article
- Exploring Plasma-Level Gut Microbiota Mediators and Pro-Inflammatory Markers in Pregnant Women with Short Cervix and Gestational Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Mouse Models of Gestational Diabetes Mellitus and Its Subtypes: Recent Insights and Pitfalls.International journal of molecular sciences · 2023Review
- A Study of the Metabolic Pathways Affected by Gestational Diabetes Mellitus: Comparison with Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2022Article
- Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low- and High-Risk Women Living in the UK.The Journal of nutrition · 2022Article
- Article
- Early pregnancy plasma fatty acid profiles of women later diagnosed with gestational diabetes.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFree fatty acids, also known as nonesterified fatty acids, are proinflammatory molecules that induce insulin resistance in nonpregnant individuals. Nevertheless, the concentration of these molecules has not been systematically addressed in pregnant women.
objectiveThis meta-analysis is aimed at evaluating the difference in free fatty acid plasma levels between women with gestational diabetes and healthy pregnant controls and their intrinsic and extrinsic determinants.
methodsWe performed a systematic search to find relevant studies published in English and Spanish using PubMed, SCOPUS, and ISI Web of Knowledge. We included observational studies measuring the mean plasma levels of free fatty acids among gestational diabetes and healthy pregnant women, with at least ten subjects being analyzed in each group. The standardized mean difference (SMD) by random effects modeling was used. Heterogeneity was assessed using Cochran's
resultsAmong the 290 identified studies, twelve were selected for analysis. A total of 2426 women were included, from which 21% were diagnosed as having gestational diabetes. There were significantly higher levels of free fatty acids among women with gestational diabetes (SMD: 0.86; 0.54-1.18;
conclusionsWomen with gestational diabetes have higher levels of free fatty acids when compared to healthy pregnant controls. More investigation is needed to assess the potential role of free fatty acids in the prediction of gestational diabetes earlier in pregnancy.
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