ReviewBioMed research international2019
Pro-Con Debate: Nitrous Oxide for Labor Analgesia.
Review in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of nitrous oxide on clinical outcome in patients undergoing cerebellopontine tumor surgery under sevoflurane anesthesia: a randomized controlled trial.Medical gas researchTrial
- Analyzing the Efficacy and Potential Risks of Nitrous Oxide for Pain Management During Labor: A Narrative Review.Clinical pharmacology : advances and applications · 2026Review
- Article
- Implementation of a quality improvement project at National University Hospital Singapore to mitigate the environmental impact of nitrous oxide.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- A Systematic Review of Contemporary and Emerging Analgesia Techniques for Natural Labor-Patient-Centered Approaches and Technological Advances.Journal of clinical medicine · 2025Review
- Cell-type specific methylation changes in the newborn child associated to obstetric pain relief.PloS one · 2024Article
- Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Review
- Analysis of the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the environmental Kuznets curve method.Turkish journal of medical sciences · 2022Article
- Nitrous oxide-induced reproductive risks: Should recreational nitrous oxide users worry?Journal of psychopharmacology (Oxford, England) · 2022Article
- Impact of Intraspinal Nerve Block Anesthesia on Intrapartum Fever and the Neonate.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- What obstetricians should know about obstetric anesthesia during the COVID-19 pandemic.Seminars in perinatology · 2020Article
- Emergency department pain management in special populations.Turkish journal of emergency medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Pro-Con debate will provide the practitioner with an evidence-based knowledge approach to assist the clinician in determining whether to employ (Pro) or not to employ (Con) this technique in the obstetrical suite for labor analgesia. Nitrous oxide has been used safely in dentistry and medicine for many centuries. However, accumulating preclinical and clinical evidence increasingly suggests previously unrecognized adverse maternal and fetal effects of nitrous oxide, which warrants reconsideration of its use in pregnant women and a more detailed informed consent. Nitrous oxide is associated with metabolic, oxidative, genotoxic, and transgenerational epigenetic effects in animals and humans that may warrant limiting its usefulness in labor. This debate will discuss and review the clinical uses, advantages, and disadvantages of nitrous oxide on occupational effects of nitrous oxide exposure, neuroapoptosis, FDA warning on inhalational anesthetics and the developing brain, research limitations, occupational exposure safety limits, effects on global warming, and potential for diversion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.