Evidence map›Paper›PMID 31531250›Full record

ArticleCase reports in hematology2019

Hairy Cell Leukemia Masquerading as Pancytopenia in Pregnancy.

Louisa Shackleton, Stephen E Langabeer, David O'Brien, Sarah L McCarron, Bridgette Byrne, Rupert Barry, Richard Flavin, C Larry Bacon, Catherine M Flynn

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Louisa ShackletonDepartment of Haematology, St. James's Hospital, Dublin 8, Ireland.
Stephen E LangabeerCancer Molecular Diagnostics, St. James's Hospital, Dublin 8, Ireland.ORCID https://orcid.org/0000-0002-6119-158X
David O'BrienDepartment of Haematology, St. James's Hospital, Dublin 8, Ireland.ORCID https://orcid.org/0000-0002-0588-7427
Sarah L McCarronCancer Molecular Diagnostics, St. James's Hospital, Dublin 8, Ireland.
Bridgette ByrneMaternal Medicine Service, Coombe Women and Infants University Hospital, Dublin 8, Ireland.
Rupert BarryDepartment of Dermatology, St. James's Hospital, Dublin 8, Ireland.
Richard FlavinDepartment of Histopathology, St. James's Hospital, Dublin 8, Ireland.
C Larry BaconDepartment of Haematology, St. James's Hospital, Dublin 8, Ireland.
Catherine M FlynnDepartment of Haematology, St. James's Hospital, Dublin 8, Ireland.
St. James's Hospital · IECoombe Women & Infants University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombocytopenia is one of the most common hematological abnormalities observed during pregnancy, and in rare cases, this may be the first indicator of an underlying hematological malignancy. Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder of which thrombocytopenia is a recurrent presenting feature. A case of pancytopenia presenting in pregnancy is described in which the thrombocytopenia persisted postpartum coincidental with a vesicular, pustular rash characterised as Sweet's syndrome. Hematological, histological, immunophenotypic, and molecular investigations confirmed the presence of HCL. The patient was treated with cladribine resulting in resolution of Sweet's syndrome, hematological remission from HCL, and achievement of a normal platelet count. This case highlights the need to maintain a wide differential diagnosis for presentations of pancytopenia or thrombocytopenia in pregnancy and the requirement for follow-up investigation of unusual cases with a lack of response to steroids or immunoglobulin.

Identifiers

PMID31531250
PMCPMC6721453
OpenAlexW2969799069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.