ArticleJournal of ophthalmology2019
Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults.
Article in Journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Effects of atropine on choroidal thickness in myopic children: a meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Effect of 0.01% Atropine on Choroidal Thickness and Ocular Growth in Pre-myopic Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Trial
- Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study.Investigative ophthalmology & visual science · 2025Trial
- Effects of tropicamide and compound tropicamide eye drops on ocular biological parameters and choroid thickness in children.BMC ophthalmology · 2025Trial
- Short-Term Effect of Stimulating the Pterygopalatine Ganglion Via Electroacupuncture on Choroidal Structure in Human Subjects.Translational vision science & technology · 2024Trial
- Choroidal Changes During and After Discontinuing Long-Term 0.01% Atropine Treatment for Myopia Control.Investigative ophthalmology & visual science · 2024Trial
- Six-month repeated irradiation of 650 nm low-level red light reduces the risk of myopia in children: a randomized controlled trial.International ophthalmology · 2023Trial
- Potential Choroidal Mechanisms Underlying Atropine's Antimyopic and Rebound Effects: A Mediation Analysis in a Randomized Clinical Trial.Investigative ophthalmology & visual science · 2023Trial
- The effect of atropine 0.01% eyedrops on relative peripheral refraction in myopic children.Eye (London, England) · 2023Trial
- Changes in subfoveal choroidal thickness in myopic children with 0.01% atropine, orthokeratology, or their combination.International ophthalmology · 2021Trial
- Additive effect of atropine eye drops and short-term retinal defocus on choroidal thickness in children with myopia.Scientific reports · 2020Trial
- Short-term effects of atropine on the retina and choroid in young adults.Eye and vision (London, England) · 2026Article
- Perspectives on Genetic and Environmental Factors in Myopia, Its Prediction, and the Future Direction of Research.Investigative ophthalmology & visual science · 2025Review
- Choroidal thickness under pilocarpine versus cyclopentolate.Scientific reports · 2025Article
- Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile.International journal of ophthalmology · 2024Article
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
- Synergistic effects of defocus-incorporated multiple segments and atropine in slowing the progression of myopia.Scientific reports · 2022Article
- Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children.Ophthalmology and therapy · 2022Article
- Daily or Less Frequent Topical 1% Atropine Slows Defocus-Induced Myopia Progression in Contact Lens-Wearing Guinea Pigs.Translational vision science & technology · 2022Article
- Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the interaction between a short period of hyperopic defocus and low-dose atropine upon the choroidal thickness and ocular biometrics of healthy myopic subjects.
methodsTwenty young adult myopic subjects had subfoveal choroidal thickness (ChT) and ocular biometry measurements taken before and 30 and 60 min following the introduction of optical blur (0.00 D and -3.00 D) combined with administration of 0.01% atropine or placebo. Each combination of optical blur and drug was tested on different days in a fixed order.
resultsThe choroid exhibited significant thinning after imposing hyperopic defocus combined with placebo (mean change of -11 ± 2
conclusionLow-dose atropine does inhibit the short-term effect of hyperopic blur on choroidal thickness and, when used alone, does cause a slight thickening of the choroid in young healthy myopic adults.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.