Evidence map›Paper›PMID 31531150›Full record

Trial reportPain research & management2019

Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome.

Yangzhi Xie, Guijuan Zhou, Yan Xu, Bing He, Yilin Wang, Rundong Ma, Yunqian Chang, Duanqun He, Chenlin Xu, Zijian Xiao

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain research & management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Migraine Comorbidities.Life (Basel, Switzerland) · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Gut microbiota and metabolite variations in a migraine mouse model.Frontiers in cellular and infection microbiology · 2023
    Article
  18. Migraine and Diet: Updates in Understanding.Current neurology and neuroscience reports · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangzhi XieThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Guijuan ZhouThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Yan XuThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Bing HeThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Yilin WangThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Rundong MaThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Yunqian ChangThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Duanqun HeThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Chenlin XuThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.
Zijian XiaoThe First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China.ORCID 0000-0001-5137-9549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7 weeks, and 14 weeks. Improvement of migraine and gut symptom was achieved at a certain time point. Reduced use of over-the-counter- (OTC-) analgesics was seen in all groups. However, use of triptans did not show significant difference. An increased serum serotonin level was seen in subjects treated with elimination diet and elimination diet combined with probiotics. IgG elimination diet combined with probiotics may be beneficial to migraine plus IBS. It may provide new insight by understanding the intricate relationship between migraine and gastrointestinal diseases.

Indexed as

AdultDouble-Blind MethodFemaleFood HypersensitivityHumansImmunoglobulin GIrritable Bowel SyndromeMaleMiddle AgedMigraine DisordersProbioticsImmunoglobulin G

Identifiers

PMID31531150
PMCPMC6721378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.