Evidence map›Paper›PMID 31531119›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2019

Antimalarial Activity of

Dawit Zewdu Wondafrash, Dayananda Bhoumik, Birhanetensay Masresha Altaye, Helen Bitew Tareke, Brhane Teklebrhan Assefa

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Article
  7. In-Vivo Anti-Malarial Activity of 80% Methanol Leaf Extract ofJournal of experimental pharmacology · 2024
    Article
  8. Article
  9. Article
  10. Antimalarial Efficacy of Hydromethanolic Root Extract and Solvent Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  11. Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021
    Review
  12. Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dawit Zewdu WondafrashDepartment of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.ORCID https://orcid.org/0000-0003-1127-6443
Dayananda BhoumikDepartment of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.ORCID https://orcid.org/0000-0001-8198-3376
Birhanetensay Masresha AltayeCollege of Medicine, Debre Berhan University, Debre Berhan, Ethiopia.ORCID https://orcid.org/0000-0001-9109-6244
Helen Bitew TarekeDepartment of Pharmacognosy, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.ORCID https://orcid.org/0000-0001-7383-4960
Brhane Teklebrhan AssefaDepartment of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.
Mekelle University · ETDebre Berhan University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria remains a major worldwide public health problem leading to death of millions of people. Spread and emergence of antimalarial drug resistance are the major challenge in malaria control. Medicinal plants are the key source of new effective antimalarial agents.

methodsThe leaf extracts were prepared and tested for oral acute toxicity according to the OECD guideline.

resultsThe acute toxicity test of the plant extract revealed that the medium lethal dose is higher than 2000 mg/kg. The crude extract of the plant exhibited significant parasitemia suppression in the four-day suppression (51.19%), curative (57.14%), and prophylactic (46.48%) tests at 600 mg/kg. The

conclusionOur findings indicated that both the crude leaf extracts and fractions of

Identifiers

PMID31531119
PMCPMC6721471
OpenAlexW2967887556

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.