Evidence map›Paper›PMID 31531037›Full record

ArticleIranian journal of veterinary research2019

Orexin A promotes granulosa cell secretion of progesterone in sheep.

M Li, N Zu, C S Zhang, M Y Xie, Y Z Liu, X J Xu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M LiMSc Student in Developmental Biology, Animal Biotechnology Laboratory, College of Veterinary Medicine, The Inner Mongolia Agricultural University, Hohehot, Inner Mongolia, China.
N ZuMSc Student in Developmental Biology, Animal Biotechnology Laboratory, College of Veterinary Medicine, The Inner Mongolia Agricultural University, Hohehot, Inner Mongolia, China.
C S ZhangMSc Student in Developmental Biology, Animal Biotechnology Laboratory, College of Veterinary Medicine, The Inner Mongolia Agricultural University, Hohehot, Inner Mongolia, China.
M Y XieMSc Student in Developmental Biology, Animal Biotechnology Laboratory, College of Veterinary Medicine, The Inner Mongolia Agricultural University, Hohehot, Inner Mongolia, China.
Y Z LiuAgriculture and Animal Husbandry Department of Inner Mongolia Autonomous Region, Hohehot, Inner Mongolia, China.
X J XuAnimal Biotechnology Laboratory, College of Veterinary Medicine, The Inner Mongolia Agricultural University, Hohehot, Inner Mongolia, China.
Inner Mongolia Agricultural University · CNInner Mongolia Academy of Agricultural & Animal Husbandry Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrexin A, a small-molecule peptide, can regulate female hormones, but limited evidence for its mechanism of activity exists in ovine.

aimsThe objective of this study was to investigate the effect of orexin A on progesterone (P4) secretion in cultured granulosa of sheep follicles.

methodsSheep ovarian granulosa were isolated and identified, pre-incubated with luteinizing hormone (LH) (2.5 IU/ml), follicle-stimulating hormone (FSH) (2.5 IU/ml), or oestrogen (1 µg/ml); and cultured

resultsThe results showed that the sheep ovarian granulosa were correctly identified. The different concentrations of orexin A promoted the secretion of P4 from granulosa in the ovine ovary compared with that in the control. The expression of StAR, 3β-HSD and P450 (CYP11) gradually increased, and then decreased with increasing concentrations of orexin A, but the expression of P450 (CYP11) decreased with the increase of time.

conclusionThese results revealed that orexin A promotes the secretion of P4 by regulating the expression of StAR, 3β-HSD, and P450 (CYP11). Understanding the mechanism underlying the promotion of P4 by orexin A could open new therapeutic possibilities in the treatment of hormone homeostasis.

Indexed as

3β-HSDOrexin AP450 (CYP11)ProgesteroneStAR

Identifiers

PMID31531037
PMCPMC6716278
OpenAlexW2996482995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.