Evidence map›Paper›PMID 31530890›Full record

ArticleScientific reports2019

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Ying Wu, Yu-Mei Chang, Anneliese J Stell, Simon L Priestnall, Eshita Sharma, Michelle R Goulart, John Gribben, Dong Xia, Oliver A Garden

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. A review of CD4Veterinary immunology and immunopathology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Modulation of Host Immune Response duringFrontiers in immunology · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Immunoregulatory Cells in Myasthenia Gravis.Frontiers in neurology · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying WuRoyal Veterinary College, London, UK.ORCID http://orcid.org/0000-0002-2264-438X
Yu-Mei ChangRoyal Veterinary College, London, UK.ORCID http://orcid.org/0000-0001-6388-9626
Anneliese J StellRoyal Veterinary College, London, UK.
Simon L PriestnallRoyal Veterinary College, London, UK.ORCID http://orcid.org/0000-0002-6027-1879
Eshita SharmaWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8663-7365
Michelle R GoulartRoyal Veterinary College, London, UK.ORCID http://orcid.org/0000-0001-8333-3908
John GribbenBarts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-8505-7430
Dong XiaRoyal Veterinary College, London, UK.ORCID http://orcid.org/0000-0003-4571-2776
Oliver A GardenRoyal Veterinary College, London, UK. ogarden@upenn.edu.ORCID http://orcid.org/0000-0002-4133-9487

Funding

Wellcome Trust
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfolios of monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs are increasingly recognised as an excellent model for many human diseases. However, insightful study of canine Tregs has been restrained by the limited availability of mAb. We therefore set out to characterise CD4

Indexed as

Conserved SequenceEvolution, MolecularGene Expression ProfilingTranscriptomeAnimalsAntigens, SurfaceBiomarkersDogsHumansImmunophenotypingMiceSignal TransductionT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsAntigens, SurfaceBiomarkers

Identifiers

PMID31530890
PMCPMC6748983

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.