Trial reportScientific reports2019
Clinical outcomes of an intraoperative surgical margin assessment using the fresh frozen section method in patients with invasive breast cancer undergoing breast-conserving surgery - a single center analysis.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Accuracy of frozen section in intraoperative margin assessment for breast-conserving surgery: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Intraoperative Frozen Section Analysis for Margin Status in Breast Conserving Therapy: a Retrospective 6-Year Experience at a Tertiary Centre in North East India.Indian journal of surgical oncology · 2026Article
- The Application of Nanomaterials in Breast Cancer.Pharmaceutics · 2025Review
- Margin Matters: Advances in Intraoperative Margin Assessment for Breast-Conserving Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- Lutetium-Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR-II Fluorescence Imaging-Guided Surgery in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Three-dimensional dynamic optical coherence tomography for breast tumor margin assessment.Biomedical optics express · 2025Article
- The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery.European journal of medical research · 2025Article
- A Hf(IV)-Coordinated NIR-II Fluorescence "Turn-On" Nanoprobe for Precise Imaging-Guided Surgery in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Virtual Staining of Nonfixed Tissue Histology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- Intraoperative Evaluation of Breast Tissues During Breast Cancer Operations Using the MasSpec Pen.JAMA network open · 2024Article
- MRI-based radiomic models to predict surgical margin status and infer tumor immune microenvironment in breast cancer patients with breast-conserving surgery: a multicenter validation study.European radiology · 2024Article
- Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues.Journal of biological engineering · 2023Article
- Blood flow on ultrasound imaging is a predictor of lump margin status in breast-conserving patients: a retrospective matching study.European journal of medical research · 2023Article
- Surgical margin assessment of bone tumours: A systematic review of current and emerging technologies.Journal of bone oncology · 2023Review
- Breast-conserving therapy versus mastectomy for breast cancer: a ten-year follow-up single-center real-world study.Gland surgery · 2022Article
- Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning.Biomedical optics express · 2022Article
- Metabolic characteristics of the various incision margins for breast cancer conservation surgery.Frontiers in oncology · 2022Article
- The Importance of the Pathological Perspective in the Management of the Invasive Lobular Carcinoma.The breast journal · 2022Article
- Development of intraoperative assessment of margins in breast conserving surgery: a narrative review.Gland surgery · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast conserving treatment (BCT) is a safe standard therapeutic method in patients with early invasive breast cancer. However, it is associated with an increased risk of residual neoplastic tissues in surgical margins. The aim of this study was to assess the outcome of the use of the intraoperative pathologic analysis by the frozen section (FS) method for evaluation of the extent of the primary lumpectomy. The study concerns a retrospective analysis of a group of 1102 patients who underwent BCT between Jan 2015 and Dec 2016. The assessment focused on the frequency of the intraoperative pathologic analysis of the primary lumpectomy extent (fresh frozen section method). The influence of the BCT specimen analysis method on the free margins width, as well as the rate and the cause of reoperation were evaluated. The intraoperative lumpectomy evaluation was performed in 45.8% (505/1102) of patients (Group I), while in the remaining 54.2% of the cases it was decided to abandon this procedure (Group II). Although in 72 (14.3%) patients the intraoperative analysis gave negative results, the margins contained residual tumor tissue (vs. 16.9% in Group II). In Group I, conversion from the previously planned BCT to mastectomy was necessary in 5.9% (30/505) patients (vs. 9.7% in Group II). The duration of surgery was 48.9 ± 17.3 minutes (Group I) and 42.9 ± 13.6 minutes (Group II). In patients undergoing BCT, the use of the intraoperative pathologic analysis by the FS method resulted in a reduction of the total number of reoperations performed due to residual tumor found in the margins following the primary lumpectomy. However, it statistically significantly extended the duration of the surgery.
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