Evidence map›Paper›PMID 31530670›Full record

ArticlemBio2019

First Days in the Life of Naive Human B Lymphocytes Infected with Epstein-Barr Virus.

Dagmar Pich, Paulina Mrozek-Gorska, Mickaël Bouvet, Atsuko Sugimoto, Ezgi Akidil, Adam Grundhoff, Stephan Hamperl, Paul D Ling, Wolfgang Hammerschmidt

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 110 citations in OpenAlex.

  1. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
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  3. Article
  4. Article
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  7. Article
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  9. Chromatin Control of EBV Infection and Latency.Current topics in microbiology and immunology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Sp140L functions as a herpesvirus restriction factor suppressing viral transcription and activating interferon-stimulated genes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dagmar PichResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany.
Paulina Mrozek-GorskaResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany.
Mickaël BouvetResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany.
Atsuko SugimotoResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany.
Ezgi AkidilResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany.
Adam GrundhoffHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Stephan HamperlInstitute of Epigenetics and Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.ORCID 0000-0002-1658-7948
Paul D LingDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Wolfgang HammerschmidtResearch Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health and German Center for Infection Research (DZIF), Munich, Germany hammerschmidt@helmholtz-muenchen.de.ORCID 0000-0002-4659-0427
Helmholtz Zentrum München · DEBaylor College of Medicine · USLeibniz Institute of Virology (LIV) · DE

Funding

Genetic Analysis of EBV's Immortalizing GenesR01CA070723 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1996 to 2017
$4.6M
NCI NIH HHS R01 CA070723
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) infects and activates resting human B lymphocytes, reprograms them, induces their proliferation, and establishes a latent infection in them. In established EBV-infected cell lines, many viral latent genes are expressed. Their roles in supporting the continuous proliferation of EBV-infected B cells

Indexed as

Cell ProliferationHerpesvirus 4, HumanB-LymphocytesCells, CulturedCell Transformation, ViralEpstein-Barr Virus Nuclear AntigensGene Expression Regulation, ViralHumansMicroRNAsViral ProteinsVirus LatencyEBNA-2 protein, Human herpesvirus 4Epstein-Barr Virus Nuclear AntigensMicroRNAsViral ProteinsB lymphocyteshuman herpesvirusesreprogrammingtransformation

Identifiers

PMID31530670
PMCPMC6751056
OpenAlexW2973766800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.