ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Posterior Hippocampal Spindle Ripples Co-occur with Neocortical Theta Bursts and Downstates-Upstates, and Phase-Lock with Parietal Spindles during NREM Sleep in Humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics.Scientific reports · 2026Article
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- Surrogates of glymphatic metrics decline and coupled sleep rhythms disruption in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- The irreplaceable role of sleep in building long-term memories: offline integration of free cortical units and its possible implication in autism.Frontiers in human neuroscience · 2026Article
- Serotonin suppresses cortical theta bursts during NREM sleep.Frontiers in pharmacology · 2026Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Functional segregation of rostral and caudal hippocampus in associative memory.Frontiers in human neuroscience · 2025Article
- Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.PLoS biology · 2024Article
- Spindle-locked ripples mediate memory reactivation during human NREM sleep.Nature communications · 2024Article
- Scalp and hippocampal sleep correlates of memory function in drug-resistant temporal lobe epilepsy.Sleep · 2024Article
- Co-occurring ripple oscillations facilitate neuronal interactions between cortical locations in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sleep Spindles Favor Emotion Regulation Over Memory Consolidation of Stressors in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep.Nature neuroscience · 2023Article
- Cortical Ripples during NREM Sleep and Waking in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effects of Anti-Seizure Medication on Sleep Spindles and Slow Waves in Drug-Resistant Epilepsy.Brain sciences · 2022Article
- Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Human Spindle Variability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep.Frontiers in neuroscience · 2022Article
- Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.Frontiers in immunology · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity and behavioral correlates. Here we report physiological differences in humans of both sexes. During NREM sleep, the human hippocampus generates sharpwave ripples (SWRs) similar to those which in rodents mark memory replay. We show that while pHC generates SWRs, it also generates approximately as many spindle ripples (SSR: ripples phase-locked to local spindles). In contrast, SSRs are rare in aHC. Like SWRs, SSRs often co-occur with neocortical theta bursts (TBs), downstates (DSs), sleep spindles (SSs), and upstates (USs), which coordinate cortico-hippocampal interactions and facilitate consolidation in rodents. SWRs co-occur with these waves in widespread cortical areas, especially frontocentral. These waves typically occur in the sequence TB-DS-SS-US, with SWRs usually occurring before SS-US. In contrast, SSRs occur ∼350 ms later, with a strong preference for co-occurrence with posterior-parietal SSs. pHC-SSs were strongly phase-locked with parietal-SSs, and pHC-SSRs were phase-coupled with pHC-SSs and parietal-SSs. Human SWRs (and associated replay events, if any) are separated by ∼5 s on average, whereas ripples on successive SSR peaks are separated by only ∼80 ms. These distinctive physiological properties of pHC-SSR enable an alternative mechanism for hippocampal engagement with neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.