ArticleVaccine2019
Diversity of Rotavirus Strains Circulating in Botswana before and after introduction of the Monovalent Rotavirus Vaccine.
Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genetic Profile of Rotavirus Type A in Children under 5 Years Old in Africa: A Systematic Review of Prevalence.Viruses · 2024Pooled it
- Genetic and Antigenic Variability in VP4 and VP7 of Group A Human Rotavirus in Yunnan, China, from 2015 to 2020.Intervirology · 2025Article
- Driving forces of continuing evolution of rotaviruses.World journal of virology · 2024Review
- Resurgent rotavirus diarrhoea outbreak five years after introduction of rotavirus vaccine in Botswana, 2018.Vaccine · 2024Review
- Rotavirus genotype diversity in Tanzania during Rotavirus vaccine implementation between 2013 and 2018.Scientific reports · 2023Article
- Genomic Analysis of G2P[4] Group A Rotaviruses in Zambia Reveals Positive Selection in Amino Acid Site 7 of Viral Protein 3.Viruses · 2023Article
- Human rotavirus VP4 and VP7 genetic diversity and detection of GII norovirus in Ibadan as Nigeria introduces rotavirus vaccine.The Journal of international medical research · 2022Article
- Evolutionary changes between pre- and post-vaccine South African group A G2P[4] rotavirus strains, 2003-2017.Microbial genomics · 2022Article
- Article
- Role of rotavirus vaccination on G9P[8] rotavirus strain during a seasonal outbreak in Japan.Human vaccines & immunotherapeutics · 2021Article
- Multiple Introductions and Predominance of Rotavirus Group A Genotype G3P[8] in Kilifi, Coastal Kenya, 4 Years after Nationwide Vaccine Introduction.Pathogens (Basel, Switzerland) · 2020Article
- Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (RotarixPathogens (Basel, Switzerland) · 2020Article
- Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018.Scientific reports · 2020Article
- Prevalence ofThe Pan African medical journal · 2020Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 6 countries.
Funding
Abstract
backgroundGlobally, rotavirus is the leading cause of acute gastroenteritis (AGE) in children aged <5 years. Botswana introduced the monovalent rotavirus vaccine (Rotarix) in July 2012. To study the impact of this vaccine on rotavirus genotypes circulating in Botswana, a comparison of the genotypes pre-vaccination (2011-2012) and post-vaccination (2013-2018) periods was conducted. SUBJECTS AND
methodsResidual samples from 284 children <5 years of age that tested positive for rotavirus by enzyme immunoassay were genotyped. One hundred and five samples were from the pre-vaccination period and 179 were from the post-vaccination period. Genotyping was performed using two multiplexed one-step reverse transcription polymerase chain reaction (RT-PCR) assays for the amplification and genotyping of rotavirus VP7 (G) and VP4 (P) genes.
resultsPrior to vaccine introduction, the predominant rotavirus circulating genotypes were G9P[8] (n = 63, 60%) and G1P[8] (n = 22, 21%). During the vaccine period, G2P[4] was the predominant genotype (n = 49, 28%), followed by G9P[8] (n = 40, 22%) and G1P[8] (n = 33, 18.5%). There was a significant decline in the prevalence of G9P[8] (p = 0.001) in the post-vaccination period. There was also a notable decline in G1P[8]. A spike in G2P[4] was observed in 2013, one year post-vaccine introduction. Rotavirus strain G3P[4] (n = 8) was only detected in the post-vaccine introduction period. In 2018 there was a marked increase in genotype G3P[8] (p = 0.0003).
conclusionsThe distribution of circulating rotavirus genotypes in Botswana changed after vaccine implementation. Further studies are needed to examine whether these changes are related to vaccination or simply represent natural secular variation.
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