ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
Perturbations of language network connectivity in primary progressive aphasia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Pooled it
- Gray matter asymmetry in asymptomatic carotid stenosis.Human brain mapping · 2021Pooled it
- A Systematic Review of Transcranial Direct Current Stimulation in Primary Progressive Aphasia: Methodological Considerations.Frontiers in aging neuroscience · 2021Pooled it
- Affective and cognitive theory of mind and associated brain functional alterations in frontotemporal dementia.Brain communications · 2026Article
- Non-invasive brain stimulation: current and future applications in neurology.Nature reviews. Neurology · 2025Review
- Posterior Cortical Atrophy: Altered Language Processing System Connectivity and Its Implications on Language Comprehension and Production.Brain sciences · 2025Article
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- Longitudinal evaluation of common and unique brain-networks in variants of primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Effects of Cerebellar Transcranial Direct Current Stimulation in Bilingual Logopenic Primary Progressive Aphasia.Journal of Alzheimer's disease reports · 2024Article
- The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.Alzheimer's research & therapy · 2023Article
- Melodic intonation therapy for non-fluent aphasia after stroke: A clinical pilot study on behavioral and DTI findings.iScience · 2023Article
- Observational
- Temporopolar regions of the human brain.Brain : a journal of neurology · 2023Article
- Spared speech fluency is associated with increased functional connectivity in the speech production network in semantic variant primary progressive aphasia.Brain communications · 2023Article
- The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.Translational psychiatry · 2022Article
- Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia.Brain : a journal of neurology · 2022Article
- Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer's Disease.Brain sciences · 2022Review
- Inter-hemispheric synchronicity and symmetry: The functional connectivity consequences of stroke and neurodegenerative disease.NeuroImage. Clinical · 2022Article
- Modularity and granularity across the language network-A primary progressive aphasia perspective.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Aphasias are caused by disruption in structural integrity and interconnectivity within a large-scale distributed language network. We investigated the distribution and behavioral consequences of altered functional connectivity in three variants of primary progressive aphasia (PPA). The goal was to clarify relationships among atrophy, resting connectivity, and the resulting behavioral changes in 73 PPA and 33 control participants. Three core regions of the left perisylvian language network: the inferior frontal gyrus (IFG), middle temporal gyrus (MTG), and anterior temporal lobe (ATL) were evaluated in agrammatic (PPA-G), logopenic (PPA-L), and semantic (PPA-S) PPA variants. All PPA groups showed decreased connectivity between IFG and MTG. The PPA-S group also showed additional loss of connectivity strength between ATL and the other language regions. Decreased connectivity between the IFG and MTG nodes in PPA-G remained significant even when controlled for the effect of atrophy. In the PPA group as a whole, IFG-MTG connectivity strength correlated with repetition and grammar scores, whereas MTG-ATL connectivity correlated with picture naming and single-word comprehension. There was no significant change in the connectivity of homologous regions in the right hemisphere. These results show that language impairments in PPA are associated with perturbations of functional connectivity within behaviorally concordant components of the language network. Altered connectivity in PPA may reflect not only the irreversible loss of cortical components indexed by atrophy, but also the dysfunction of remaining neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.