ArticleBJPsych open2019
Basic symptoms in offspring of parents with mood and psychotic disorders.
Article in BJPsych open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Basic symptoms of psychosis-from historical foundations to current evidence.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Review
- Exploring the role of TNF-α, TGF-β, and IL-6 serum levels in categorical and noncategorical models of mood and psychosis.Scientific reports · 2024Article
- Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.Frontiers in psychology · 2024Article
- Parental mental disorders and offspring schizotypy in middle childhood: an intergenerational record linkage study.Social psychiatry and psychiatric epidemiology · 2023Article
- Toward Generalizable and Transdiagnostic Tools for Psychosis Prediction: An Independent Validation and Improvement of the NAPLS-2 Risk Calculator in the Multisite PRONIA Cohort.Biological psychiatry · 2021Article
- Parental mental illness and their offspring's mental health in Rwanda: neuropsychiatric hospital of Rwanda.BMC psychology · 2021Article
- Intergenerational transmission of psychiatric disorders: the 1987 Finnish Birth Cohort study.European child & adolescent psychiatry · 2021Article
- Editorial: Children, Adolescents and Families With Severe Mental Illness: Toward a Comprehensive Early Identification of Risk.Frontiers in psychiatry · 2021Article
- The Role of Gut Microbiota in the High-Risk Construct of Severe Mental Disorders: A Mini Review.Frontiers in psychiatry · 2020Review
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBasic symptoms, defined as subjectively perceived disturbances in thought, perception and other essential mental processes, have been established as a predictor of psychotic disorders. However, the relationship between basic symptoms and family history of a transdiagnostic range of severe mental illness, including major depressive disorder, bipolar disorder and schizophrenia, has not been examined.
aimsWe sought to test whether non-severe mood disorders and severe mood and psychotic disorders in parents is associated with increased basic symptoms in their biological offspring.
methodWe measured basic symptoms using the Schizophrenia Proneness Instrument - Child and Youth Version in 332 youth aged 8-26 years, including 93 offspring of control parents, 92 offspring of a parent with non-severe mood disorders, and 147 offspring of a parent with severe mood and psychotic disorders. We tested the relationships between parent mental illness and offspring basic symptoms in mixed-effects linear regression models.
resultsOffspring of a parent with severe mood and psychotic disorders (B = 0.69, 95% CI 0.22-1.16, P = 0.004) or illness with psychotic features (B = 0.68, 95% CI 0.09-1.27, P = 0.023) had significantly higher basic symptom scores than control offspring. Offspring of a parent with non-severe mood disorders reported intermediate levels of basic symptoms, that did not significantly differ from control offspring.
conclusionsBasic symptoms during childhood are a marker of familial risk of psychopathology that is related to severity and is not specific to psychotic illness. DECLARATION OF INTEREST: None.
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