ReviewClinical epigenetics2019
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
Review in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between long-term and short-term exposure to outdoor air pollution and stillbirth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Small extracellular vesicles: connecting early life exposure outcomes to air pollution during pregnancy to early childhood health.Environmental health : a global access science source · 2025Pooled it
- Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial.Environment international · 2025Trial
- Is black carbon associated with cardiovascular and cancer mortality? Evidence from the Malmö Diet and Cancer Cohort.Global health action · 2026Article
- Maternal Exposure to Air Pollution During Early Pregnancy and Congenital Heart Disease: An Exploratory Case-Control Analysis from Delhi NCR.Indian journal of pediatrics · 2026Article
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
- Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.European journal of human genetics : EJHG · 2026Review
- ToxiTaRGET: a multi-omics database for toxicant-responsive molecular targets.Nature communications · 2026Article
- Uterine Vulnerability to Environmental PMInternational journal of molecular sciences · 2026Article
- Critical windows and risk thresholds of prenatal mixed air pollutant exposure for oligohydramnios: Evidence from a population‑based study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Prenatal exposure to air pollution and the development of autism spectrum disorder from birth to adolescence: A nationwide Danish cohort study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Windows of susceptibility to fine particulate matter components for fetal birth weight: a birth cohort study.BMC public health · 2026Article
- Autism Spectrum Disorder in the Genomic Era: A Comprehensive Review of Etiology, Precision Diagnostics, Clinical Outcomes, and Emerging Gene-Editing Therapies.Neuropsychiatric disease and treatment · 2026Review
- Maternal and perinatal risk factors for necrotizing enterocolitis.World journal of pediatric surgery · 2026Review
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- Interactive and joint associations of prenatal ozone and PMBMC public health · 2025Article
- Special Issue "Molecular Insights into the Developmental Origins of Health and Disease".International journal of molecular sciences · 2025Article
- A biological and ethical assessment of whether humans could or should reproduce in space.NPJ microgravity · 2025Review
- Late-Onset Preeclampsia is characterised by Accelerated Placental Aging.bioRxiv : the preprint server for biology · 2025Article
- Ambient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort.Environmental research · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the "Developmental Origins of Health and Disease" (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution exposure during pregnancy adversely affects newborn outcomes such as birth weight and preterm birth, there is a need to pay attention to underlying modes of action to better understand not only these air pollution-induced early health effects but also its later-life consequences. In this review, we give an overview of air pollution-induced placental molecular alterations observed in the ENVIRONAGE birth cohort and evaluate the existing evidence. In general, we showed that prenatal exposure to air pollution is associated with nitrosative stress and epigenetic alterations in the placenta. Adversely affected CpG targets were involved in cellular processes including DNA repair, circadian rhythm, and energy metabolism. For miRNA expression, specific air pollution exposure windows were associated with altered miR-20a, miR-21, miR-146a, and miR-222 expression. Early-life aging markers including telomere length and mitochondrial DNA content are associated with air pollution exposure during pregnancy. Previously, we proposed the air pollution-induced telomere-mitochondrial aging hypothesis with a direct link between telomeres and mitochondria. Here, we extend this view with a potential co-interaction of different biological mechanisms on the level of placental oxidative stress, epigenetics, aging, and energy metabolism. Investigating the placenta is an opportunity for future research as it may help to understand the fundamental biology underpinning the DOHaD concept through the interactions between the underlying modes of action, prenatal environment, and disease risk in later life. To prevent lasting consequences from early-life exposures of air pollution, policy makers should get a basic understanding of biomolecular consequences and transgenerational risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.