ReviewCurrent aging science2020
Cholesterol and Dementia: A Long and Complicated Relationship.
Review in Current aging science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Cardiometabolic factors and risk of dementia in people with type 2 diabetes in England: a large retrospective cohort study.BMJ open diabetes research & care · 2026Article
- Conditions for Nutritional Care of Elderly Individuals with Dementia and Their Caregivers: An Exploratory Study.Nutrients · 2025Article
- Factors associated with dementia among older people in Malaysia: Findings from National Health and Morbidity Survey.Australasian journal on ageing · 2025Article
- Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients.CNS neuroscience & therapeutics · 2024Article
- Validation of the brain health index in the European Prevention of Alzheimer's Dementia cohort.Cerebral circulation - cognition and behavior · 2024Article
- Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study.European journal of epidemiology · 2023Article
- Exploring what progress is being made in the development of health promotion material for vascular dementia: A systematic review of the evidence.Aging medicine (Milton (N.S.W)) · 2023Review
- Role of Oxysterols in the Activation of the NLRP3 Inflammasome as a Potential Pharmacological Approach in Alzheimer's Disease.Current neuropharmacology · 2023Review
- Exploring the Role of Lipid-Binding Proteins and Oxidative Stress in Neurodegenerative Disorders: A Focus on the Neuroprotective Effects of Nutraceutical Supplementation and Physical Exercise.Antioxidants (Basel, Switzerland) · 2022Review
- Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females.Nutrients · 2022Article
- Association of Familial Hypercholesterolemia and Statin Use With Risk of Dementia in Norway.JAMA network open · 2022Article
- Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats.The Journal of veterinary medical science · 2022Article
- Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort.Frontiers in nutrition · 2022Article
- Blood metabolites predicting mild cognitive impairment in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease.Frontiers in molecular neuroscience · 2022Review
- Neurodegenerative Diseases and Cholesterol: Seeing the Field Through the Players.Frontiers in aging neuroscience · 2021Review
- Burning Fog: Cognitive Impairment in Burning Mouth Syndrome.Frontiers in aging neuroscience · 2021Article
- Promoting Successful Cognitive Aging: A Ten-Year Update.Journal of Alzheimer's disease : JAD · 2021Review
- Statin therapy and risk of Alzheimer's and age-related neurodegenerative diseases.Alzheimer's & dementia (New York, N. Y.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a huge demand for efficient strategies for maintaining cognitive wellbeing with age, especially in the context of population aging. Dementia constitutes the main reason for disability and dependency in the elderly. Identification of potential risk and protective factors, as well as determinants of conversion from MCI to dementia, is therefore crucial. In case of Alzheimer's disease, the most prevalent dementia syndrome amongst the members of modern societies, neurodegenerative processes in the brain can begin many years before first clinical symptoms appear. First functional changes typically mean advanced neuron loss, therefore, the earliest possible diagnosis is critical for implementation of promising early pharmaceutical interventions.
objectiveThe study aimed to discuss the relationships between both circulating and brain cholesterol with cognition, and explore its potential role in early diagnosis of cognitive disorders.
methodsLiterature review.
resultsThe causal role of high cholesterol levels in AD or MCI has not been confirmed. It has been postulated that plasma levels of 24(S)-OHC can potentially be used as an early biochemical marker of altered cholesterol homeostasis in the CNS. Some studies brought conflicting results, finding normal or lowered levels of 24(S)-OHC in dementia patients compared to controls. In spite of decades of research on the relationship between cholesterol and dementia, so far, no single trusted indicator of an early cognitive deterioration has been identified.
conclusionThe current state of knowledge makes the use of cholesterol markers of cognitive decline in clinical practice impossible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.