ArticleProceedings. Biological sciences2019
Evolution of ageing as a tangle of trade-offs: energy versus function.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed.
- An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan.Nature communications · 2026Article
- Selection for Function in Early Life: Implications for Early-Onset Pathologies.Evolutionary applications · 2026Article
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- Lifespan Predicts Mitochondrial Substitution Rates across Vertebrates, but Methodology Matters.Genome biology and evolution · 2026Article
- Fast females, slow males: accelerated ageing and reproductive senescence inEvolution letters · 2026Article
- Epigenetic aging and lifespan reflect reproductive history in the Finnish Twin Cohort.Nature communications · 2026Article
- Repair and regeneration across the lifespan: an ontogenetic perspective.Frontiers in aging · 2026Review
- Review
- Systems genetics of lifespan and senescence in Drosophila melanogaster.BMC biology · 2025Article
- Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rewarding touch limits lifespan through neural to intestinal signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Metabolic regulation of behavior by the intestinal enzyme FMO-2.Science advances · 2025Article
- No Evidence That Life History Strategies Shape Within-Body Mosaics of Ageing.Molecular ecology · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- Elevational variation in trichomes of the alpine subnival woolly plant Eriophyton wallichii: abiotic and biotic correlates and impacts on other traits.Annals of botany · 2025Article
- Condition-dependent effects of knockdown of autophagy onbioRxiv : the preprint server for biology · 2025Article
- Optimising Age-Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments.Aging cell · 2025Article
- Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population.Evolution letters · 2025Article
- Worker Survival and Egg Production-But Not Transcriptional Activity-Respond to Queen Number in the Highly Polygynous, Invasive Ant Tapinoma magnum.Molecular ecology · 2025Article
- Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite tremendous progress in recent years, our understanding of the evolution of ageing is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing energy demands of reproduction and somatic maintenance leading to slow accumulation of unrepaired cellular damage with age. However, the centrality of energy trade-offs in ageing has been increasingly challenged as studies in different organisms have uncoupled the trade-off between reproduction and longevity. An emerging theory is that ageing instead is caused by biological processes that are optimized for early-life function but become harmful when they continue to run-on unabated in late life. This idea builds on the realization that early-life regulation of gene expression can break down in late life because natural selection is too weak to optimize it. Empirical evidence increasingly supports the hypothesis that suboptimal gene expression in adulthood can result in physiological malfunction leading to organismal senescence. We argue that the current state of the art in the study of ageing contradicts the widely held view that energy trade-offs between growth, reproduction, and longevity are the universal underpinning of senescence. Future research should focus on understanding the relative contribution of energy and function trade-offs to the evolution and expression of ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.