ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020
Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed.
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Review
- Rehabilitation Nutrition for Tendon and Ligament Injuries: From Collagen Remodeling to Return-to-Activity and Sport.Healthcare (Basel, Switzerland) · 2026Review
- Sequential vascular and neural changes underlying the progression of patellar tendinopathy.Journal of orthopaedic surgery and research · 2026Article
- Non-Operative Management of a Complete ACL Rupture With the Cross-Bracing Protocol in an Elite Australian Rules Football Athlete.Clinical case reports · 2026Article
- Dual-Responsive Hydrogels Engineer Anisotropic Cellular Microenvironment to Modulate Stem Cell Organization and Fate.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Engineered NestinJournal of extracellular vesicles · 2026Article
- Review
- Tendon gel using the film model method promotes ligament healing in rabbits.Archives of orthopaedic and trauma surgery · 2026Article
- Mesenchymal stem cell derived exosomes and injectable platelet-rich fibrin enhance SDFT healing in a donkey tendonitis model.Scientific reports · 2026Article
- Real-time indocyanine green perfusion assessment demonstrates regional vascularity and loss of perfusion in the anterior cruciate ligament during knee arthroscopy.Journal of experimental orthopaedics · 2026Article
- Regenerative effects of secretome from tendon-derived stem cells and treadmill training on Achilles tendon healing in rats.Histochemistry and cell biology · 2026Article
- Structural characterization of newt tendon regeneration after complete transection: In vivo two-photon imaging and transmission electron microscopy.Journal of anatomy · 2026Article
- Tendon healing in the era of regenerative medicine: literature review.Annals of translational medicine · 2026Review
- Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Article
- Directed Cell Self-Assembly to Form Tendon and Muscle Models for Studying Early Stages of Musculoskeletal Tissue Formation.Journal of biomechanical engineering · 2026Article
- Silk cryogel and electrospun scaffold characterization for bone-tendon interface applications.Frontiers in bioengineering and biotechnology · 2026Article
- Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management.Biomaterials research · 2026Review
- ATG5-overexpressing MSCs improve ligament healing with an associated shift toward M2 macrophage polarization in aged rats.Open medicine (Warsaw, Poland) · 2026Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Ligament and tendon injuries are common problems in orthopedics. There is a need for treatments that can expedite nonoperative healing or improve the efficacy of surgical repair or reconstruction of ligaments and tendons. Successful biologically-based attempts at repair and reconstruction would require a thorough understanding of normal tendon and ligament healing. The inflammatory, proliferative, and remodeling phases, and the cells involved in tendon and ligament healing will be reviewed. Then, current research efforts focusing on biologically-based treatments of ligament and tendon injuries will be summarized, with a focus on stem cells endogenous to tendons and ligaments. Statement of clinical significance: This paper details mechanisms of ligament and tendon healing, as well as attempts to apply stem cells to ligament and tendon healing. Understanding of these topics could lead to more efficacious therapies to treat ligament and tendon injuries. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:7-12, 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.