ArticleDiabetic medicine : a journal of the British Diabetic Association2020
Severe neonatal hypoglycaemia and intrapartum glycaemic control in pregnancies complicated by type 1, type 2 and gestational diabetes.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05647798 (Management of Intrapartum Glycemia in Gestational Diabetic Mothers), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Management of Intrapartum Glycemia in Gestational Diabetic Mothers: A Randomized Controlled Trial
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta-analysis of observational studies.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review and meta-analysis.PloS one · 2026Pooled it
- Intrapartum maternal glycaemic control for the prevention of neonatal hypoglycaemia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes.International journal of environmental research and public health · 2022Pooled it
- Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes.Diabetologia · 2023Trial
- Neonatal Glycemic Status in Infants of Diabetic Mothers in Sulaimaniyah Governorate, Iraq.International journal of endocrinology and metabolism · 2026Article
- Comparison of postpartum depression, anxiety, sleep quality and neonatal outcomes in mothers with pregestational and gestational diabetes.BMC pediatrics · 2025Article
- Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases.iScience · 2025Article
- Diabetes Mellitus in Pregnancy: Implications for Obstetric Anesthesia.Anesthesiology · 2025Review
- Glycaemic control in labour with diabetes: GILD, a scoping study.Health technology assessment (Winchester, England) · 2025Article
- Maternal high fat and high sugar diet impacts on key DNA methylation enzymes in offspring brain in a sex-specific manner.Journal of neuroendocrinology · 2025Article
- Intrapartum Glycemic Control and Clinical Outcomes.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Glucose Control During Labour and Delivery in Type 1 Diabetes - An Update on Current Evidence.Current diabetes reports · 2024Review
- Glycemic control before delivery using continuous glucose monitoring and neonatal outcomes.American journal of obstetrics & gynecology MFM · 2024Article
- Development and internal validation of a clinical score to predict neonatal hypoglycaemia in women with gestational diabetes.Endocrine · 2024Article
- Clinical Effectiveness of Continuous Glucose Monitoring in Pregnancies Affected by Type 1 Diabetes.Diabetes technology & therapeutics · 2024Article
- Continuous Glucose Monitoring Metrics in High-Risk Pregnant Women with Type 2 Diabetes.Diabetes technology & therapeutics · 2023Observational
- Management of type 2 diabetes in pregnancy: a narrative review.Frontiers in endocrinology · 2023Review
- Reexamining intrapartum glucose control in patients with diabetes and risk of neonatal hypoglycemia.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Epigenetic Changes in Neonates Born to Mothers With Gestational Diabetes Mellitus May Be Associated With Neonatal Hypoglycaemia.Frontiers in endocrinology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine if in-target intrapartum glucose control is associated with neonatal hypoglycaemia in women with type 1, type 2 or gestational diabetes.
methodsThis was a retrospective cohort study of pregnant women with diabetes and their neonates. The primary exposure was in-target glucose control, defined as all capillary glucose values within the range 3.5-6.5 mmol/l during the intrapartum period. The primary outcome, neonatal hypoglycaemia, was defined as treatment with intravenous dextrose therapy. Multiple logistic regression was used to examine the association between maternal intrapartum glycaemic control and neonatal hypoglycaemia, adjusting for covariates.
resultsIntrapartum glucose testing was available for 157 (86.3%), 267 (76.3%) and 3256 (52.4%) women with type 1, type 2 and gestational diabetes, respectively. In the univariate analysis, in-target glycaemic control was significantly associated with neonatal hypoglycaemia in women with gestational diabetes, but not in women with type 1 or 2 diabetes. However, after adjustment for important neonatal factors (large for gestational age, preterm delivery and infant sex), intrapartum in-target glycaemic control was not significantly associated with neonatal hypoglycaemia in women regardless of diabetes type [adjusted odds ratios 0.4 (95% CI 0.1, 1.4), 0.7 (95% CI 0.3, 1.3) and 0.7 (95% CI 0.5, 1.0) for women with type 1, type 2 and gestational diabetes, respectively].
conclusionsThere was no significant association between in-target glycaemic control and neonatal hypoglycaemia after adjustment for neonatal factors. Given the high risk of maternal hypoglycaemia and the resources required, future trials should consider whether more relaxed intrapartum glycaemic targets may be safer and yield similar neonatal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.