ArticleAngewandte Chemie (International ed. in English)2019
Carboamination of Unactivated Alkenes through Three-Component Radical Conjugate Addition.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Nickel-Catalyzed Twofold Conjunctive Coupling via Philicity-Alternating Radical Relay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Harnessing Bifunctional N-Benzoyloxyamides for Photoredox Amidative Dual Functionalizations of Alkenes.Angewandte Chemie (International ed. in English) · 2025Article
- Enhanced Photoredox Activity in Nitrogen-Doped Carbon Nitride for Heterogeneous Nitrogen and Oxygen Radical Reactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aminoalkylation of Alkenes Enabled by Triple Radical Sorting.Journal of the American Chemical Society · 2025Article
- Cu-Catalyzed Three-Component Alkene Carboamination: Mechanistic Insights and Rational Design to Overcome Limitations.Journal of the American Chemical Society · 2024Article
- Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy.Nature communications · 2023Article
- Cu-Catalyzed Three-Component Carboamination of Electron Deficient Olefins.Organic letters · 2023Article
- Metal-free photosensitized radical relay 1,4-carboimination across two distinct olefins.Chemical science · 2023Article
- Highly Selective Radical Relay 1,4-Oxyimination of Two Electronically Differentiated Olefins.Journal of the American Chemical Society · 2022Article
- Three-component 1,2-carboamination of vinyl boronic estersChemical science · 2021Article
- Article
- Three-Component Aminoarylation of Electron-Rich Alkenes by Merging Photoredox with Nickel Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
- Copper-Catalyzed Three-Component Alkene Carbofunctionalization: C-N, C-O, and C-C Bond Formation from a Single Reaction Platform.Organic letters · 2021Article
- Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Intermolecular oxidative amination of unactivated alkenes by dual photoredox and copper catalysis.Chemical science · 2020Article
- Three-component three-bond forming cascadeChemical science · 2020Article
- Intra- and intermolecular Fe-catalyzed dicarbofunctionalization of vinyl cyclopropanes.Chemical science · 2020Article
- Photosensitized Intermolecular Carboimination of Alkenes through the Persistent Radical Effect.Angewandte Chemie (International ed. in English) · 2020Article
- Exploiting Imine Photochemistry for Masked N-Centered Radical Reactivity.Angewandte Chemie (International ed. in English) · 2019Article
- Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(spNature communications · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
Two-component Giese type radical additions are highly practical and established reactions. Herein, three-component radical conjugate additions of unactivated alkenes to Michael acceptors are reported. Amidyl radicals, oxidatively generated from α-amido oxy acids using redox catalysis, act as the third reaction component which add to the unactivated alkenes. The adduct radicals engage in Giese type additions to Michael acceptors to provide, after reduction, the three-component products in an overall alkene carboamination reaction. Transformations which can be conducted under practical mild conditions feature high functional group tolerance and broad substrate scope.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.