Evidence map›Paper›PMID 31529664›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Enzyme-Mediated Endogenous and Bioorthogonal Control of a DNAzyme Fluorescent Sensor for Imaging Metal Ions in Living Cells.

Yao Lin, Zhenglin Yang, Ryan J Lake, Chengbin Zheng, Yi Lu

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 109 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Fluorescence-Based Multimodal DNA Logic Gates.Nanomaterials (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Article
  10. Ratiometric Detection of ZnChemistry (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Simultaneous FeScience advances · 2023
    Article
  13. Article
  14. Review
  15. Construction and Application of DNAzyme-based Nanodevices.Chemical research in Chinese universities · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yao LinDepartment of Chemistry, Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Zhenglin YangDepartment of Chemistry, Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.ORCID 0000-0003-2743-5779
Ryan J LakeDepartment of Chemistry, Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Chengbin ZhengKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan, 610064, China.
Yi LuDepartment of Chemistry, Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.ORCID 0000-0003-1221-6709
University of Illinois Urbana-Champaign · USSichuan University · CN

Funding

Selection and Sensing Applications of DNAzymes Selective for Paramagnetic Metal IonsR01GM124316 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LU, YI · 2017 to 2020
$1.4M
Novel DNAzyme sensors for lithium and sodium to understand cellular and molecular mechanisms of lithium treatment of bipolar disorderR21MH110975 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LU, YI · 2016 to 2017
$401k
National Natural Science Foundation of China 21622508NIGMS NIH HHS R01 GM124316NIH HHS GM124316NIH HHS MH110975NIMH NIH HHS R21 MH110975
6 · The paper itself

Abstract

Bioorthogonal control of metal-ion sensors for imaging metal ions in living cells is important for understanding the distribution and fluctuation of metal ions. Reported here is the endogenous and bioorthogonal activation of a DNAzyme fluorescent sensor containing an 18-base pair recognition site of a homing endonuclease (I-SceI), which is found by chance only once in 7×10

Indexed as

Biosensing TechniquesCatalysisDeoxyribonucleases, Type II Site-SpecificDNADNA, CatalyticFluorescent DyesHeLa CellsHumansMagnesiumMolecular ImagingSpectrometry, FluorescenceDeoxyribonucleases, Type II Site-SpecificDNADNA, CatalyticFluorescent DyesMagnesiumDNAfluorescenceimaging agentsmagnesiumsensors

Identifiers

PMID31529664
PMCPMC7174831
OpenAlexW2974762820

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.