Evidence map›Paper›PMID 31529624›Full record

Observational studyJournal of the American Geriatrics Society2020

Association Between Osteoarthritis and Social Isolation: Data From the EPOSA Study.

Paola Siviero, Nicola Veronese, Toby Smith, Brendon Stubbs, Federica Limongi, Sabina Zambon, Elaine M Dennison, Mark Edwards, Cyrus Cooper, Erik J Timmermans and 12 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Interactive AI Routines for Pain Symptoms and Loneliness in Older Adults.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025
    Trial
  5. Trial
  6. Emerging therapies for knee osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  7. Review
  8. Chronic disease and social isolation among Canadians: evidence from the 2022 Mental Health and Access to Care Survey.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Adapting an Osteoarthritis Peer Mentorship Intervention for Remote Delivery to People Experiencing Socioeconomic Disadvantage: A Multi-Method Approach.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Paola SivieroNational Research Council, Institute of Neuroscience-Aging Branch, Padova, Italy.ORCID 0000-0001-6567-5808
Nicola VeroneseNational Research Council, Institute of Neuroscience-Aging Branch, Padova, Italy.
Toby SmithNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Brendon StubbsPhysiotherapy Department, South London and Maudsley NHS Foundation Trust, London, United Kingdom.
Federica LimongiNational Research Council, Institute of Neuroscience-Aging Branch, Padova, Italy.
Sabina ZambonDepartment of Medicina, University of Padova, Padua, Italy.
Elaine M DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
Mark EdwardsMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
Cyrus CooperNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Erik J TimmermansDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Natasja M van SchoorDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Suzan van der PasDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Laura A SchaapDepartment of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Michael D DenkingerAGAPLESION Bethesda Hospital, Geriatric Research Unit/Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Richard PeterInstitute of the History, Philosophy and Ethics of Medicine, Ulm University, Ulm, Germany.
Florian HerbolsheimerDepartment of Gerontology, Simon Fraser University, Vancouver, British Columbia, Canada.
Ángel OteroDepartment of Preventive Medicine and Public Health, Unit of Primary Care and Family Medicine, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.
Maria Victoria CastellDepartment of Preventive Medicine and Public Health, Unit of Primary Care and Family Medicine, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dorly J H DeegDepartment of Epidemiology and Biostatistics, Amsterdam UMC, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Stefania MaggiNational Research Council, Institute of Neuroscience-Aging Branch, Padova, Italy.
EPOSA Research Group

Funding

Arthritis Research UKBritish Heart FoundationDepartment of Health ICA-CL-2017-03-001Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Versus Arthritis 19583
6 · The paper itself

Abstract

objectiveTo determine whether there is an association between osteoarthritis (OA) and incident social isolation using data from the European Project on OSteoArthritis (EPOSA) study.

designProspective, observational study with 12 to 18 months of follow-up.

settingCommunity dwelling.

participantsOlder people living in six European countries. MEASUREMENTS: Social isolation was assessed using the Lubben Social Network Scale and the Maastricht Social Participation Profile. Clinical OA of the hip, knee, and hand was assessed according to American College of Rheumatology criteria. Demographic characteristics, including age, sex, multijoint pain, and medical comorbidities, were assessed.

resultsOf the 1967 individuals with complete baseline and follow-up data, 382 (19%) were socially isolated and 1585 were nonsocially isolated at baseline; of these individuals, 222 (13.9%) experienced social isolation during follow-up. Using logistic regression analyses, after adjustment for age, sex, and country, four factors were significantly associated with incident social isolation: clinical OA, cognitive impairment, depression, and worse walking time. Compared to those without OA at any site or with only hand OA, clinical OA of the hip and/or knee, combined or not with hand OA, led to a 1.47 times increased risk of social isolation (95% confidence interval = 1.03-2.09).

conclusionClinical OA, present in one or two sites of the hip and knee, or in two or three sites of the hip, knee, and hand, increased the risk of social isolation, adjusting for cognitive impairment and depression and worse walking times. Clinicians should be aware that individuals with OA may be at greater risk of social isolation. J Am Geriatr Soc 68:87-95, 2019.

Indexed as

ComorbidityHandAgedAged, 80 and overCognitive DysfunctionDepressionEuropeFemaleHumansIndependent LivingMaleMiddle AgedOsteoarthritis, HipOsteoarthritis, KneePainProspective StudiesepidemiologyEPOSAosteoarthritissocial isolation

Identifiers

PMID31529624
PMCPMC6954097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.