Evidence map›Paper›PMID 31529353›Full record

ArticleIntensive care medicine2019

Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study.

Shannon M Fernando, Danial Qureshi, Peter Tanuseputro, Eddy Fan, Laveena Munshi, Bram Rochwerg, Robert Talarico, Damon C Scales, Daniel Brodie, Sonny Dhanani and 4 more

Abstract read
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In one paragraph

Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Cardiogenic Shock: Clinical Management, Outcomes and Future Directions.Journal of cardiovascular development and disease · 2026
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  14. Year in Review 2022: Noteworthy Literature in Cardiac Anesthesiology.Seminars in cardiothoracic and vascular anesthesia · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shannon M FernandoDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada. sfernando@qmed.ca.ORCID http://orcid.org/0000-0003-4549-4289
Danial QureshiICES, Toronto, ON, Canada.
Peter TanuseputroICES, Toronto, ON, Canada.
Eddy FanInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Laveena MunshiInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Bram RochwergDepartment of Medicine, Division of Critical Care, McMaster University, Hamilton, ON, Canada.
Robert TalaricoClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Damon C ScalesICES, Toronto, ON, Canada.
Daniel BrodieDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA.
Sonny DhananiDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Anne-Marie GuerguerianInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.
Sam D ShemieDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Kednapa ThavornICES, Toronto, ON, Canada.
Kwadwo KyeremantengDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExtracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in critically ill patients. Little is known about population-level short- and long-term outcomes following ECMO, including healthcare use and health system cost across a wide range of sectors.

methodsPopulation-based cohort study in Ontario, Canada (October 1, 2009-March 31, 2017) of adult patients (≥ 18 years) receiving ECMO for cardiorespiratory support. We captured outcomes through linkage to health administrative databases. Primary outcome was mortality during hospitalization, as well as at 7 days, 30 days, 1 year, 2 years, and 5 years following ECMO initiation. We analyzed health system costs (in Canadian dollars) in the 1 year following the date of the index admission.

resultsA total of 692 patients were included. Mean (standard deviation [SD]) age was 51.3 (16.0) years. Median (interquartile range [IQR]) time to ECMO initiation from date of admission was 2 (0-9) days. In-hospital mortality was 40.0%. Mortality at 1 year, 2 years, and 5 years was 45.1%, 49.0%, and 57.4%, respectively. Among survivors, 78.4% were discharged home, while 21.2% were discharged to continuing care. Median (IQR) total costs in the 1 year following admission among all patients were Canadian $130,157 (Canadian $58,645-Canadian $240,763), of which Canadian $91,192 (Canadian $38,507-Canadian $184,728) were attributed to inpatient care.

conclusionsHospital mortality among critically ill adults receiving ECMO for advanced cardiopulmonary support is relatively high, but does not markedly increase in the years following discharge. Survivors are more likely to be discharged home than to continuing care. Median costs are high, but largely reflect inpatient hospital costs, and not costs incurred following discharge.

Indexed as

AdultAgedCohort StudiesCritical IllnessExtracorporeal Membrane OxygenationFemaleHeart ArrestHumansMaleMiddle AgedMortalityOntarioRespiratory Distress SyndromeRetrospective StudiesShock, CardiogenicTreatment OutcomeAcute respiratory distress syndromeCardiac arrestCardiogenic shockECMOExtracorporeal membrane oxygenationHealth services

Identifiers

PMID31529353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.