ArticleThe Journal of clinical endocrinology and metabolism2020
Association between Body Mass Index and Stroke Risk Among Patients with Type 2 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Obesity's Role in Stroke Incidence Among Smokers:Saudi medical journal · 2026Article
- Association between calculated remnant cholesterol levels and incident risks of Alzheimer's disease among elderly patients with type 2 diabetes: a real-world study.Frontiers in endocrinology · 2024Article
- Trends in obesity prevalence and cardiometabolic risk factor control in US adults with diabetes, 1999-2020.Obesity (Silver Spring, Md.) · 2023Article
- Association of novel lipid indicators with the risk of stroke among participants in Central China: a population-based prospective study.Frontiers in endocrinology · 2023Article
- Non-linear dose-response relationship between body mass index and stroke risk in middle-aged and elderly Chinese men: a nationwide Longitudinal Cohort Study from CHARLS.Frontiers in endocrinology · 2023Article
- Effects of a Lifestyle Intervention in Young Women with GDM and Subsequent Diabetes.Nutrients · 2022Article
- Association between abdominal obesity indices and risk of cardiovascular events in Chinese populations with type 2 diabetes: a prospective cohort study.Cardiovascular diabetology · 2022Article
- Association Between a Body Shape Index and Subclinical Carotid Atherosclerosis in Population Free of Cardiovascular and Cerebrovascular Diseases.Journal of atherosclerosis and thrombosis · 2022Article
- Combined consideration of body mass index and waist circumference identifies obesity patterns associated with risk of stroke in a Chinese prospective cohort study.BMC public health · 2022Article
- Article
- Prevalence of and factors associated with stroke in hypertensive patients in Thailand from 2014 to 2018: A nationwide cross-sectional study.Scientific reports · 2021Article
- Different Indicators of Adiposity and Fat Distribution and Cardiometabolic Risk Factors in Patients with Type 2 Diabetes.Obesity (Silver Spring, Md.) · 2021Article
- Estimating the effects of body mass index and central obesity on stroke in diabetics and non-diabetics using targeted maximum likelihood estimation: Atherosclerosis Risk in Communities study.Obesity science & practice · 2020Article
- Practical use of electronic health records among patients with diabetes in scientific research.Chinese medical journal · 2020Review
- Exploring Gender-Specific Stroke Risks in Diabetic Patients: Insights from a Retrospective Analysis of Contributing Factors.Iranian journal of nursing and midwifery researchArticle
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Authors and funding
8 authors.
Funding
Abstract
contextVery few studies focused on the association between body mass index (BMI) and stroke risk among patients with diabetes.
objectiveWe aimed to investigate the association between BMI and stroke risk in patients with type 2 diabetes.
designDemographic, anthropometric, laboratory, and medication information were extracted from the National Patient-Centered Clinical Research Network common data model.
participantsWe performed a retrospective cohort study of 67 086 patients with type 2 diabetes.
main outcome measuresIncident stroke including both ischemic and hemorrhagic stroke were defined.
resultsDuring a mean follow up of 3.74 years. 8918 incident stroke events occurred. Multivariable-adjusted hazard ratios across different categories of BMI at baseline (18.5-24.9 [reference group], 25.0-29.9, 30.0-34.9, 35.0-39.9, and ≥40 kg/m2) were 1.00, 0.92, 0.85, 0.74, and 0.63 (Ptrend <0.001) for total stroke; 1.00, 0.93, 0.88, 0.77, and 0.65 (Ptrend <0.001) for ischemic stroke; and 1.00, 0.79, 0.50, 0.50, and 0.41 (Ptrend <0.001) for hemorrhagic stroke, respectively. When we used an updated mean value of BMI, the graded inverse association of body mass index with stroke risk did not change. This linear association was consistent among patients of different subgroups. Further sensitivity analysis excluding patients who were diagnosed stroke within 6 months after first diagnosis of type 2 diabetes or including non-smokers only also confirmed our findings.
conclusionThe present study found an inverse association between BMI and the risk of total, ischemic, and hemorrhagic stroke among patients with type 2 diabetes. More clinical and molecular insights are still needed in explaining these findings.
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